Neuropeptides
Volume 44, Issue 5 , Pages 385-389 , October 2010

Communication of substance P, calcitonin-gene-related neuropeptides and chemokine receptor 4 (CXCR4) in cord blood hematopoietic stem cells

  • Somayeh Shahrokhi

      Affiliations

    • Department of Immunology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
    • ,
  • Massoumeh Ebtekar

      Affiliations

    • Department of Immunology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
    • Corresponding Author InformationCorresponding author. Address: Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, P.O. Box 14115-331, Tehran, Iran. Tel./fax: +98 21 8288 3891.
    • ,
  • Kamran Alimoghaddam

      Affiliations

    • Hematology, Oncology and Stem Cell Transplantation Research Center of Tehran University of Medical Sciences, Iran
    • Cord Blood Bank of Iran, Tehran University of Medical Sciences, Iran
    • Corresponding Author InformationCorresponding author at: Hematology, Oncology and Stem Cell Transplantation Research Center of Tehran University of Medical Sciences, P.O. Box 14114, Tehran, Iran. Tel.: +98 21 8490 2626; fax: +98 21 8800 4140.
    • ,
  • Zohreh Sharifi

      Affiliations

    • Research Center, Department of Virology, Iranian Blood Transfusion Organization, Tehran, Iran
    • ,
  • Seyed Hamidolah Ghaffari

      Affiliations

    • Hematology, Oncology and Stem Cell Transplantation Research Center of Tehran University of Medical Sciences, Iran
    • ,
  • Ali Akbar Pourfathollah

      Affiliations

    • Department of Immunology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
    • ,
  • Maryam Kheirandish

      Affiliations

    • Research Center, Department of Immunology, Iranian Blood Transfusion Organization, Tehran, Iran
    • ,
  • Mahboobeh Mohseni

      Affiliations

    • Department of Immunology, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
    • ,
  • Ardeshir Ghavamzadeh

      Affiliations

    • Hematology, Oncology and Stem Cell Transplantation Research Center of Tehran University of Medical Sciences, Iran

Received 5 April 2010 ,Accepted 11 June 2010.

References 

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  2. Burger JA, Spoo A, et al. CXCR4 chemokine receptors (CD184) and alpha4beta1 integrins mediate spontaneous migration of human CD34+ progenitors and acute myeloid leukaemia cells beneath marrow stromal cells (pseudoemperipolesis). Br. J. Haematol. 2003;122(4):579–589
  3. Cancelas JA, Jansen M, et al. The role of chemokine activation of Rac GTPases in hematopoietic stem cell marrow homing, retention, and peripheral mobilization. Exp. Hematol. 2006;34(8):976–985
  4. Cohen PA, Gower AC, et al. A neurokinin-1 receptor antagonist that reduces intraabdominal adhesion formation increases peritoneal matrix metalloproteinase activity. Wound Repair Regen. 2007;15(6):800–808
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  6. Greco SJ, Corcoran KE, et al. Tachykinins in the emerging immune system: relevance to bone marrow homeostasis and maintenance of hematopoietic stem cells. Front. Biosci. 2004;9:1782–1793
  7. Jo DY, Rafii S, et al. Chemotaxis of primitive hematopoietic cells in response to stromal cell-derived factor-1. J. Clin. Invest. 2000;105(1):101–111
  8. Kahn J, Byk T, et al. Overexpression of CXCR4 on human CD34+ progenitors increases their proliferation, migration, and NOD/SCID repopulation. Blood. 2004;103(8):2942–2949
  9. Lee YH, Lee YA, et al. Homing-associated cell adhesion molecules and cell cycle status on the nucleated cells in the bone marrow, mobilized peripheral blood and cord blood. J. Korean Med. Sci. 2004;19(4):523–528
  10. Liu B, Liao C, et al. Significance of increasing adhesion of cord blood hematopoietic cells and a new method: platelet microparticles. Am. J. Hematol. 2003;74(3):216–217
  11. Mao P, Xu L, et al. Effect of different cytokine combinations on the expression of CD49d and CXCR4 and ex vivo expansion of umbilical cord blood mononuclear cells. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2006;14(2):318–321
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  13. Nowicki M, Ostalska-Nowicka D, et al. The significance of substance P in physiological and malignant haematopoiesis. J. Clin. Pathol. 2007;60(7):749–755
  14. Shahrokhi S, Ebtekar M, et al. Substance P and calcitonin gene-related neuropeptides as novel growth factors for ex vivo expansion of cord blood CD34(+) hematopoietic stem cells. Growth Factors. 2010;28(1):66–73
  15. Surbek DV, Steinmann C, et al. Developmental changes in adhesion molecule expressions in umbilical cord blood CD34 hematopoietic progenitor and stem cells. Am. J. Obstet. Gynecol. 2000;183(5):1152–1157
  16. Voermans C, Gerritsen WR, et al. Increased migration of cord blood-derived CD34+ cells, as compared to bone marrow and mobilized peripheral blood CD34+ cells across uncoated or fibronectin-coated filters. Exp. Hematol. 1999;27(12):1806–1814
  17. Watt, S.M., Forde, S.P., 2008. The central role of the chemokine receptor, CXCR4, in haemopoietic stem cell transplantation: will CXCR4 antagonists contribute to the treatment of blood disorders? Vox Sang 94(1), 18–32.
  18. Wu H, Guan C, et al. Upregulation of substance P receptor expression by calcitonin gene-related peptide, a possible cooperative action of two neuropeptides involved in airway inflammation. Pulm. Pharmacol. Ther. 2007;20(5):513–524
  19. Zhang Y, Wittner M, et al. Identification of CXCR4 as a new nitric oxide-regulated gene in human CD34+ cells. Stem Cells. 2007;25(1):211–219
  20. Zheng Y, Watanabe N, et al. Ex vivo manipulation of umbilical cord blood-derived hematopoietic stem/progenitor cells with recombinant human stem cell factor can up-regulate levels of homing-essential molecules to increase their transmigratory potential. Exp. Hematol. 2003;31(12):1237–1246
  21. Zheng YZ, Zhang L, et al. Differential expression of a homing-related molecule repertoire among umbilical cord blood, mobilized peripheral blood and bone marrow-derived hematopoietic stem/progenitor cells.. Zhonghua Xue Ye Xue Za Zhi. 2004;25(12):736–739

PII: S0143-4179(10)00066-1

doi: 10.1016/j.npep.2010.06.002

Neuropeptides
Volume 44, Issue 5 , Pages 385-389 , October 2010

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