Neuropeptides
Volume 44, Issue 5 , Pages 437-444 , October 2010

Effects of rat/mouse hemokinin-1, human hemokinin-1 and human hemokinin-1(4-11), mammalian tachykinin peptides, on rate and perfusion pressure in the isolated guinea pig heart

  • Zi-Qing Kong

      Affiliations

    • Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, and Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, 222 Tian Shui South Road, Lanzhou, Gansu 730000, China
    • Both authors contributed equally to this work.
  • ,
  • Wen-Le Yang

      Affiliations

    • Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, and Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, 222 Tian Shui South Road, Lanzhou, Gansu 730000, China
    • Both authors contributed equally to this work.
  • ,
  • Yan Tao

      Affiliations

    • Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, and Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, 222 Tian Shui South Road, Lanzhou, Gansu 730000, China
  • ,
  • Xiao-Mei Shi

      Affiliations

    • Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, and Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, 222 Tian Shui South Road, Lanzhou, Gansu 730000, China
  • ,
  • Cai-Yun Fu

      Affiliations

    • Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, and Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, 222 Tian Shui South Road, Lanzhou, Gansu 730000, China
  • ,
  • Rui-Fei Zhao

      Affiliations

    • Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, and Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, 222 Tian Shui South Road, Lanzhou, Gansu 730000, China
  • ,
  • Rui Wang

      Affiliations

    • Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, and Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, 222 Tian Shui South Road, Lanzhou, Gansu 730000, China
    • State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong
    • Corresponding Author InformationCorresponding author at: Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Lanzhou University, 222 Tian Shui South Road, Lanzhou, Gansu 730000, China. Tel.: +86 931 8912567/852 34003755; fax: +86 931 8911255/852 23649932.

Received 20 December 2009 ,Accepted 20 April 2010.

References 

  1. Bellucci F, Carini F, Catalani C, Cucchi P, Lecci A, Meini S, et al. Pharmacological profile of the novel mammalian tachykinin, hemokinin 1. Br. J. Pharmacol. 2002;135:266–274
  2. Berger A, Paige CJ. Hemokinin-1 has Substance P-like function in U-251 MG astrocytoma cells: a pharmacological and functional study. J. Neuroimmunol. 2005;164:48–56
  3. Bossaller C, Habib GB, Yamamoto H, Williams C, Wells S, Henry PD. Impaired muscarinic endothelium-dependent relaxation and cyclic guanosine 5-monophosphate formation in atherosclerotic human coronary artery and rabbit aorta. J. Clin. Invest. 1987;79:170–174
  4. Broadley KJ. The Langendorff heart preparation: reappraisal of its role as a research and teaching model for coronary vasoactive drug. J. Pharmacol. Methods. 1979;2:143–156
  5. Camarda V, Rizzi A, Calo G, Guerrini RS, Regoli D. Pharmacological profile of hemokinin 1: a novel member of the tachykinin family. Life Sci. 2002;71:363–370
  6. Cascieri MA, Huang RR, Fong TM, Cheung AH, Sadowski S, Ber E, et al. Determination of the amino acid residues in substance P conferring selectivity and specificity for the rat neurokinin receptors. Mol. Pharmacol. 1992;41:1096–1099
  7. Chang YZ, Hoover DB, Hancock JC, Smith FM. Tachykinin receptor subtypes in the isolated guinea pig heart and their role in mediating responses to neurokinin A. J. Pharmacol. Exp. Ther. 2000;294:147–154
  8. Chiao H, Caldwell RW. Local cardiac effects of substance P: roles of acetylcholine and noradrenaling. Br. J. Pharmacol. 1995;114:283–288
  9. Dolezel S, Gerová M, Gero J, Sládek T, Vasku J. Adrenergic innervation of the coronary arteries and the myocardium. Acta Anat. 1978;100:306–316
  10. Duffy RA, Hedrick JA, Randolph G, Morgan CA, Cohen-Williams ME, Vassileva G, et al. Centrally administered hemokinin-1 (HK-1), a neurokinin tachykinin NK1 receptor agonist, produces substance P-like behavioral effects in mice and gerbils. Neuropharmacology. 2003;45:242–250
  11. Fu CY, Kong ZQ, Long Y, Chen Q, Wang R. Cardiovascular responses to rat/mouse hemokinin-1, a mammalian tachykinin peptide: systemic study in anesthetized rats. Eur. J. Pharmacol. 2007;572:175–181
  12. Gulati N, Mathison R, Huggel H, Regoli D, Beny JL. Effects of neurokinins on the isolated pig coronary artery. Eur. J. Pharmacol. 1987;137:149–154
  13. Holzer-Petsche U. Tachykinin receptors in gastrointestinal motility. Regul. Pept. 1995;57:19–42
  14. Hoover DB. Effects of substance p on rate and perfusion pressure in the isolated guinea pig heart. J. Pharmocol. Exp. Ther. 1990;252:179–184
  15. Hoover DB, Chang Y, Hancock JC. Characterization of responses to neurokinin A in the isolated perfused guinea pig heart. Am. J. Physiol. 1998;275:1803–1811
  16. Hoover DB, Ganote CE, Ferguson SM, Blakely RD, Parsons RL. Localization of cholinergic innervation in guinea pig heart by immunohistochemistry for high-affinity choline transporters. Cardiovasc. Res. 2004;62:112–121
  17. Hoover DB, Hancock JC. Distribution of substance P binding sites in guinea pig heart and pharmacological effects of substance P. J. Auton. Nerv. Syst. 1988;23:189–197
  18. Hoover DB, Hossler PE. Vasoconstrictor and vasodilator responses to neurokinin A in isolated guinea pig hearts. Peptides. 1993;14:29–36
  19. Horackova M, Armour JA. Role of peripheral autonomic neurones in maintaining adequate cardiac function. Cardiovasc. Res. 1995;30:326–335
  20. Huang MH, Friend DS, Sunday ME, Singh K, Haley K, Austen KF, et al. An intrinsic adrenergic system in mammalian heart. J. Clin. Invest. 1996;98:1298–1303
  21. Ingi T, Kitajima Y, Minamitake Y, Nakanishi S. Characterization of ligand-binding properties and selectivities of three rat tachykinin receptors by transfection and functional expression of their cloned cDNAs in mammalian cells. J. Pharmacol. Exp. Ther. 1991;259:968–975
  22. Kong ZQ, Fu CY, Chen Q, Wang R. Cardiovascular responses to intravenous administration of human hemokinin-1 and its truncated form hemokinin-1(4-11) in anesthetized rats. Eur. J. Pharmacol. 2008;590:310–316
  23. Krokhina EM. The adrenergic component of the effector heart innervation: histochemical study by the method of fluorescent microscopy. Acta Anat. 1969;74:214–227
  24. Kurtz MM, Wang R, Clements MK, Cascieri MA, Austin CP, Cunningham BR, et al. Identification, localization and receptor characterization of novel mammalian substance P-like peptides. Gene. 2002;296:205–212
  25. Lever JD, Ahmed M, Irvine G. Neuromuscular and intercellular relationships in the coronary arterioles: a morphological and quantitative study by light and electron microscopy. J. Anat. 1965;99:829–840
  26. Maggi CA. The mammalian tachykinin receptors. Gen. Pharmacol. 1995;26:911–944
  27. Morteau O, Lu B, Gerard C, Gerard NP. Hemokinin 1 is a full agonist at the substance P receptor. Nat. Immunol. 2001;2:1088
  28. Nelson DA, Bost KL. Non-neuronal mammalian tachykinin expression. Front. Biosci. 2004;9:2166–2176
  29. Nielsen KC, Owman C. Difference in cardiac adrenergic innervation between hibernators and non-hibernating mammals. Acta Physiol. Scand. 1968;316:1–30
  30. Page NM. Hemokinins and endokinins. Cell. Mol. Life Sci. 2004;61:1652–1663
  31. Page NM, Bell NJ, Gardiner SM, Manyonda IT, Brayley KJ, Strange PG, et al. Characterization of the endokinins: human tachykinins with cardiovascular activity. Proc. Natl. Acad. Sci. USA. 2003;100:6245–6250
  32. Rice PJ, Taylor DA, Valinski WA, Head RJ, Fleming WW. Norepinephrine depletion and sensitivity changes in rat heart induced by pretreatment with reserpine. J. Pharmocol. Exp. Ther. 1987;240:764–771
  33. Severini C, Improta G, Falconieri-Erspamer G, Salvadori S, Erspamer V. The tachykinin peptide family. Pharmacol. Rev. 2002;54:285–322
  34. Stanovnik L, Logonder-Mlinsek M, Erjavec F. The effect of compound 48/80, substance P and pentagastrin on the isolated guinea pig atrium. Agents Action. 1986;18:197–200
  35. Sutherland FJ, Hearse DJ. The isolated blood and perfusion fluid perfused heart. Pharmacol. Res. 2000;6:613–627
  36. Zhang Y, Lu L, Furlonger C, Wu GE, Paige CJ. Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis. Nat. Immunol. 2000;1:392–397
  37. Zhang LL, Tompkins JD, Hancock JC, Hoover DB. Substance P modulates nicotinic responses of intracardiac neurons to acetylcholine in the guinea pig. Am. J. Physiol. Regulat. Integr. Comp. Physiol. 2001;281:1792–1800

PII: S0143-4179(10)00047-8

doi: 10.1016/j.npep.2010.04.006

Neuropeptides
Volume 44, Issue 5 , Pages 437-444 , October 2010