Neuropeptides
Volume 44, Issue 5 , Pages 445-451 , October 2010

Conditional stimulation by galanin of saccharin and ethanol consumption under free and response contingent access

  • I.M. McNamara

      Affiliations

    • Current address: Accenture, 2001 Market Street, Philadelphia, PA, USA.
    • ,
  • J.K. Robinson

      Affiliations

    • Corresponding Author InformationCorresponding author. Tel.: +1 631 632 7832.

Received 1 December 2009 ,Accepted 14 April 2010.

References 

  1. Barton C, York DA, Bray GA. Opioid receptor subtype control of galanin-induced feeding. Peptides. 1996;17:237–240
  2. Beck B. Neuropeptides and obesity. Nutrition. 2000;16:916–923
  3. Berridge KC, Robinson TE. Parsing reward. Trends Neurosci. 2003;26:507–513
  4. Berridge KC, Robinson TE. What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?. Brain Res. Rev. 1998;28:309–369
  5. Biggs TA, Myers RD. Naltrexone and amperozide modify chocolate and saccharin drinking in high alcohol-preferring P rats. Pharmacol. Biochem. Behav. 1998;60:407–413
  6. Brewer A, Robinson JK. Galanin stimulation of feeding is blocked by the addition of a response requirement. Behav. Neurosci. 2008;122:949–953
  7. Brewer A, Langel Ü, Robinson JK. Intracerebroventricularly administration of galanin decreases free water intake and operant reinforcer efficacy in water-restricted rats. Neuropeptides. 2005;39:117–124
  8. Brewer A, Langel Ü, Robinson JK. Intracerebroventricularly administered galanin does not alter operant reaction time or differentially reinforced high rate schedule operant responding in rats. Neurosci. Lett. 2004;38:55–61
  9. Burazin TC, Larm JA, Gundlach AL. Regulation by osmotic stimuli of galanin-R1 receptor expression in magnocellular neurones of the paraventricular and supraoptic nuclei of the rat. J. Neuroendocrinol. 2001;13:330–358
  10. Carroll ME, Lac ST. Dietary additives and the acquisition of cocaine self-administration in rats. Psychopharmacology (Berl). 1998;137:81–89
  11. Craig W. Appetites and aversions as constituents of instincts. Proc. Natl. Acad. Sci. USA. 1917;3:685–688
  12. Crawley JN. Functional interactions of galanin and acetylcholine: relevance to memory and Alzheimer’s disease. Behav. Brain Res. 1993;57:133–141
  13. Crawley JN. The role of galanin in feeding behavior. Neuropeptides. 1999;33:369–375
  14. Dube MG, Horvath TL, Leranth C, Kalra PS, Kalra SP. Naloxone reduces the feeding evoked by intracerebroventricular galanin injection. Physiol. Behav. 1994;56:811–813
  15. Fraley GS, Thomas-Smith SE, Acohido BV, Steiner RA, Clifton DK. Stimulation of sexual behavior in the male rat by galanin-like peptide. Horm. Behav. 2004;46:551–557
  16. Furudono Y, Ando C, Yamamoto C, Kobashi M, Yamamoto T. Involvement of specific orexigenic neuropeptides in sweetener-induced overconsumption in rats. Behav. Brain. Res. 2006;175:241–248
  17. Gundlach AL. Galanin/GALP and galanin receptors: role in central control of feeding, body weight/obesity and reproduction?. Eur. J. Pharmacol. 2002;440:255–268
  18. Holmes A, Picciotto MR. Galanin: a novel therapeutic target for depression, anxiety disorders and drug addiction?. CNS Neurol. Disord. Drug Targets. 2006;5:225–232
  19. Holmes A, Yang RJ, Crawley JN. Evaluation of an anxiety-related phenotype in galanin overexpressing transgenic mice. J. Mol. Neurosci. 2002;18:151–165
  20. Hursh SR. Behavioral economics of drug self-administration and drug abuse policy. J. Exp. Anal. Behav. 1991;56:377–393
  21. Inui-Yamamoto C, Furudono Y, Yamamoto T. Hedonics of taste influence the gastric emptying in rats. Physiol. Behav. 2009;96:717–722
  22. Karatayev O, Baylan J, Weed V, Chang S, Wynick D, Leibowitz SF. Galanin knockout mice show disturbances in ethanol consumption and expression of hypothalamic peptides that stimulate ethanol intake. Alcohol Clin. Exp. Res. 2010;34:72–80
  23. Karlsson RM, Holmes A. Galanin as a modulator of anxiety and depression and a therapeutic target for affective disease. Amino Acids. 2006;31:231–239
  24. Kelley AE, Baldo BA, Pratt WE, Will MJ. Corticostriatal-hypothalamic circuitry and food motivation: integration of energy, action and reward. Physiol. Behav. 2005;86:773–795
  25. Koenig JI, Hooi S, Gabriel SM, Martin JB. Potential involvement of galanin in the regulation of fluid homeostasis in the rat. Regul. Pept. 1989;24:81–86
  26. Kuteeva E, Wardi T, Hokfelt T, Ogren SO. Galanin enhances and a galanin antagonist attenuates depression-like behaviour in the rat. Eur. Neuropsychopharmacol. 2007;17:64–69
  27. Kyrkouli SE, Stanley BG, Leibowitz SF. Galanin: stimulation of feeding induced by medial hypothalamic injection of this novel peptide. Eur. J. Pharmacol. 1986;12:159–160
  28. Kyrkouli SE, Stanley BG, Seirafi RD, Leibowitz SF. Stimulation of feeding by galanin: anatomical localization and behavioral specificity of this peptide’s effects in the brain. Peptides. 1990;11:995–1001
  29. Landry M, Aman K, Hökfelt T. Galanin-R1 receptor in anterior and mid-hypothalamus: distribution and regulation. J. Comp. Neurol. 1998;399:321–340
  30. Landry M, Roche D, Calas A. Short-term effects of centrally administered galanin on the hyperosmotically stimulated expression of vasopressin in the rat hypothalamus. An in situ hybridization and immunohistochemistry study. Neuroendocrinology. 1995;61:393–404
  31. Landry M, Vila-Porcile E, Hokfelt T, Calas A. Differential routing of coexisting neuropeptides in vasopressin neurons. Eur. J. Neurosci. 2003;17:579–589
  32. Leibowitz SF. Regulation and effects of hypothalamic galanin: relation to dietary fat, alcohol ingestion, circulating lipids and energy homeostasis. Neuropeptides. 2005;39:327–332
  33. Leibowitz SF. Overconsumption of dietary fat and alcohol: mechanisms involving lipids and hypothalamic peptides. Physiol. Behav. 2007;91:513–521
  34. Lewis MJ, Johnson DF, Waldman D, Leibowitz SF, Hoebel BG. Galanin microinjection in the third ventricle increases voluntary ethanol intake. Alcohol Clin. Exp. Res. 2004;28:1822–1828
  35. Lieber CS, Lasker JM, DeCarli LM, Saeli J, Wojtowicz T. Role of acetone, dietary fat and total energy intake in induction of hepatic microsomal ethanol oxidizing system. J. Pharmacol. Exp. Ther. 1988;247:791–795
  36. Mastropaolo J, Nadi NS, Ostrowski NL, Crawley JN. Galanin antagonizes acetylcholine on a memory task in basal forebrain-lesioned rats. Proc. Natl. Acad. Sci. USA. 1988;85:9841–9845
  37. Melander T, Hokfelt T, Rokaeus A. Distribution of galanin-like immunoreactivity in the rat central nervous system. J. Comp. Neurol. 1986;248:475–517
  38. Mitsukawa K, Lu X, Bartfai T. Galanin, galanin receptors and drug targets. Cell. Mol. Life Sci. 2008;65:1796–1805
  39. Poggioli R, Rasori E, Bertolini A. Galanin inhibits sexual behavior in male rats. Eur. J. Pharmacol. 1992;213:87–90
  40. Rada P, Avena NM, Leibowitz SF, Hoebel BG. Ethanol intake is increased by injection of galanin in the paraventricular nucleus and reduced by a galanin antagonist. Alcohol. 2004;33:91–97
  41. Rimondini R, Thorsell A, Heilig M. Suppression of ethanol self-administration by the neuropeptide Y (NPY) Y2 receptor antagonist BIIE0246: evidence for sensitization in rats with a history of dependence. Neurosci. Lett. 2005;2005(375):129–133
  42. Robinson JK, Brewer A. Galanin: a potential role in mesolimbic dopamine-mediated instrumental behavior. Neurosci. Biobehav. Rev. 2008;32:1485–1493
  43. Salamone JD. Functions of mesolimbic dopamine: changing concepts and shifting paradigms. Psychopharmacology. 2007;191:461–482
  44. Salamone JD, Correa M, Mingote SM, Weber SM. Beyond the reward hypothesis: alternative functions of nucleus accumbens dopamine. Curr. Opin. Pharmacol. 2005;5:34–41
  45. Salamone JD, Correa M, Mingote SM, Weber SM, Farrar AM. Nucleus accumbens dopamine and the forebrain circuitry involved in behavioral activation and effort-related decision making: implications of understanding anergia and psychomotor slowing and depression. Curr. Psychiatr. Rev. 2006;2:267–280
  46. Salamone JD, Steinpreis RE, McCullough LD, Smith P, Grebel D, Mahan K. Haloperidol and nucleus accumbens dopamine depletion suppress lever pressing for food but increase free food consumption in a novel food-choice procedure. Psychopharmacology. 1991;104:515–521
  47. Salamone JD, Correa M, Farrar AM, Nunes EJ, Pardo M., 2009. Dopamine, behavioral economics, and effort. Front Behav. Neurosci. 3, 13.
  48. Samson HH, Sharpe AL, Denning C. Initiation of ethanol self-administration in the rat using sucrose substitution in a sipper-tube procedure. Psychopharmacology (Berl). 1999;147:274–279
  49. Schneider ER, Rada P, Darby RD, Leibowitz SF, Hoebel BG. Orexigenic peptides and alcohol intake: differential effects of orexin, galanin, and ghrelin. Alcohol Clin. Exp. Res. 2007;3:1858–1865
  50. Sherrington CS. The Integrative Action of the Nervous System. New York: Scribner; 1906;
  51. Stephens MK, Riley AL. Naloxone-precipitated conditioned taste aversions in morphine-dependent Fischer (F344) and Lewis rat strains. Pharmacol. Biochem. Behav. 2009;92:60–67
  52. Sundstrom E, Archer T, Melander T, Hokfelt T. Galanin impairs acquisition but not retrieval of spatial memory in rats studied in the Morris swim maze. Neurosci. Lett. 1988;88:331–335
  53. Tatemoto K, Rokaeus A, Jornvall H, McDonald TJ, Mutt V. Galanin – a novel biologically active peptide from porcine intestine. FEBS Lett. 1983;164:124–128
  54. Tordoff MG. How do non-nutritive sweeteners increase food intake?. Appetite. 1988;11:5–11
  55. Ukai M, Miura M, Kameyama T. Effects of galanin on passive avoidance response, elevated plus-maze learning, and spontaneous alternation performance in mice. Peptides. 1995;16:1283–1286
  56. Wise RA. Neuroleptics and operant behavior: the anhedonia hypothesis. Behav. Brain Sci. 1982;5:39–87
  57. Wise RA. The role of reward pathways in the development of drug dependence. Pharmacol. Ther. 1987;35:227–263
  58. Zhang M, Gosnell BA, Kelley AE. Intake of high-fat food is selectively enhanced by mu opioid receptor stimulation within the nucleus accumbens. J. Pharmacol. Exp. Ther. 1998;285(2):908–914

PII: S0143-4179(10)00044-2

doi: 10.1016/j.npep.2010.04.003

Neuropeptides
Volume 44, Issue 5 , Pages 445-451 , October 2010

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