Neuropeptides
Volume 44, Issue 3 , Pages 273-278 , June 2010

The amino-terminal region of hemokinin-1 regulates the induction of thermal hyperalgesia in rats

  • N. Sunakawa

      Affiliations

    • Division of Oral and Maxillofacial Surgery, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki 889-1692, Japan
    • ,
  • R. Naono

      Affiliations

    • Division of Neurobiology, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki 889-1692, Japan
    • ,
  • T. Ikeda

      Affiliations

    • Division of Neurobiology, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki 889-1692, Japan
    • ,
  • O. Matsushima

      Affiliations

    • Department of Environmental Information, Faculty of Environmental Studies, Hiroshima Institute of Technology, 2-1-1, Miyake, Saeki-ku, Hiroshima 731-5193, Japan
    • ,
  • S. Sakoda

      Affiliations

    • Division of Oral and Maxillofacial Surgery, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki 889-1692, Japan
    • ,
  • T. Nishimori

      Affiliations

    • Division of Neurobiology, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki 889-1692, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 985 85 0992; fax: +81 985 85 7323.

Received 6 November 2009 ,Accepted 26 January 2010.

References 

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  2. Camarda V, Rizzi A, Calo G, Guerrini R, Salvadori S, Regoli D. Pharmacological profile of hemokinin 1: a novel member of the tachykinin family. Life Sci. 2002;71:363–370
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  4. Dirig DM, Yaksh TL. Thermal hyperalgesia in rat evoked by intrathecal substance P at multiple stimulus intensities reflects an increase in the gain of nociceptive processing. Neurosci. Lett. 1996;220:93–96
  5. Duffy RA, Hedrick JA, Randolp G, Morgan CA, Cohen-Williams ME, Vassileva G, et al. Centrally administered hemokinin-1 (HK-1), a neurokinin NK1 receptor agonist, produces substance P-like behavioral effects in mice and gerbils. Neuropharmacology. 2003;45:242–250
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  12. Naono R, Nakayama T, Ikeda T, Matsushima O, Nishimori T. Leucine at the carboxyl-terminal of endokinin C and D contributes to elicitation of the antagonistic effect on substance P in rat pain processing. Brain Res. 2007;1165:71–80
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  19. Yoshioka D, Takebuchi F, Nishimori T, Naono R, Ikeda T, Nakayama T. Intrathecal administration of the common carboxyl-terminal decapeptide in endokinin A and endokinin B evokes scratching behavior and thermal hyperalgesia in the rat. Neurosci. Lett. 2006;410:193–197
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PII: S0143-4179(10)00007-7

doi: 10.1016/j.npep.2010.01.003

Neuropeptides
Volume 44, Issue 3 , Pages 273-278 , June 2010

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