Neuropeptides
Volume 44, Issue 3 , Pages 269-272 , June 2010

Influence of tachykinin NK2 receptors on intestinal sensitivity and motility in newborn rats

  • M. Tramontana

      Affiliations

    • Department of Pharmacology, Menarini Ricerche S.p.A., Florence, Italy
    • ,
  • S. Evangelista

      Affiliations

    • Preclinical Development, Menarini Ricerche S.p.A., Florence, Italy
    • Corresponding Author InformationCorresponding author. Address: Department of Preclinical Development, Menarini Ricerche S.p.A., Via Sette Santi 1, 50131 Florence, Italy. Tel.: +39 055 5680519; fax: +39 055 5680510.
    • ,
  • S. Giuliani

      Affiliations

    • Department of Pharmacology, Menarini Ricerche S.p.A., Florence, Italy
    • ,
  • S. Manzini

      Affiliations

    • Preclinical Development, Menarini Ricerche S.p.A., Florence, Italy
    • ,
  • S. Robelet

      Affiliations

    • Syncrosome, Campus Scientifique de Saint-Jerome, Marseille, France
    • ,
  • V. Girod

      Affiliations

    • Syncrosome, Campus Scientifique de Saint-Jerome, Marseille, France
    • ,
  • C.A. Maggi

      Affiliations

    • Department of Pharmacology, Menarini Ricerche S.p.A., Florence, Italy

Received 4 November 2009 ,Accepted 9 January 2010.

References 

  1. Barreau F, Ferrier L, Fioramonti J, Bueno L. New insights in the etiology and pathophysiology of irritable bowel syndrome: contribution of neonatal stress models. Pediatr. Res. 2007;62:240–245
  2. Birder LA, Kiss S, de Groat WC, Lecci A, Maggi CA. Effect of nepadutant, a neurokinin 2 tachykinin receptor antagonist, on immediate-early gene expression after trinitrobenzenesulfonic acid-induced colitis in the rat. J. Pharmacol. Exp. Ther. 2003;304:272–276
  3. Carini F, Lecci A, Tramontana M, Giuliani S, Maggi CA. Tachykinin NK(2) receptors and enhancement of cholinergic transmission in the inflamed rat colon: an in vivo motility study. Br. J. Pharmacol. 2001;133:1107–1113
  4. Catalioto RM, Criscuoli M, Cucchi P, et al. MEN 11420 (nepadutant), a novel glycosylated bicyclic peptide tachykinin NK2 receptor antagonist. Br. J. Pharmacol. 1998;123:81–91
  5. Evangelista S. Involvement of tachykinins in intestinal inflammation. Curr. Pharm. Des. 2001;7:19–30
  6. Holzer P, Holzer-Petsche U. Tachykinin receptors in the gut: physiological and pathological implications. Curr. Opin. Pharmacol. 2001;1:583–590
  7. Laird JM, Olivar T, Lopez-Garcia JA, Maggi CA, Cervero F. Responses of rat spinal neurons to distension of inflamed colon: role of tachykinin NK2 receptors. Neuropharmacology. 2001;40:696–701
  8. Lecci A, Tramontana M, Giuliani S, Maggi CA. Role of tachykinin NK1 and NK2 receptors on colonic motility in anesthetized rats: effect of agonists. Can. J. Physiol. Pharmacol. 1997;75:582–586
  9. Lecci A, Carini F, Tramontana M, et al. Nepadutant pharmacokinetics and dose–effect relationships as tachykinin NK2 receptor antagonist are altered by intestinal inflammation in rodent models. J. Pharmacol. Exp. Ther. 2001;299:247–254
  10. Lordal M, Navalesi G, Theodorsson E, et al. A novel tachykinin NK2 receptor antagonist prevents motility-stimulating effects of neurokinin A in small intestine. Br. J. Pharmacol. 2001;134:215–223
  11. Santicioli P, Giuliani S, Patacchini R, Tramontana M, Criscuoli M, Maggi CA. MEN 11420, a potent and selective tachykinin NK2 receptor antagonist in the guinea-pig and human colon. Naunyn Schmiedebergs Arch. Pharmacol. 1997;356:678–688
  12. Shimizu Y, Matsuyama H, Shiina T, Takewaki T, Furness JB. Tachykinin and their functions in the gastrointestinal tract. Cell. Mol. Life Sci. 2008;65:295–311
  13. Toulouse M, Coelho AM, Fioramonti J, Lecci A, Maggi CA, Bueno L. Role of tachykinin NK2 receptors in normal and altered rectal sensitivity in rats. Br. J. Pharmacol. 2000;129:193–199
  14. Tramontana M, Maggi CA, Evangelista S. Spasmolytic effect of the NK2 receptor selective antagonist, MEN 10,627, in the rat small intestine. Jpn. J. Pharmacol. 1994;65:281–283
  15. Winston J, Shenoy M, Medley D, Nanwadekar A, Pasricha PJ. The vanilloid receptor initiates and maintains colonic hypersensitivity induced by neonatal colon irritation. Gastroenterology. 2007;132:615–627

PII: S0143-4179(10)00006-5

doi: 10.1016/j.npep.2010.01.002

Neuropeptides
Volume 44, Issue 3 , Pages 269-272 , June 2010

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