Neuropeptides
Volume 44, Issue 3 , Pages 261-268 , June 2010

Y4 receptors and pancreatic polypeptide regulate food intake via hypothalamic orexin and brain-derived neurotropic factor dependent pathways

  • Amanda Sainsbury

      Affiliations

    • Neuroscience Program, Garvan Institute of Medical Research, St. Vincent’s Hospital, 384 Victoria St., Darlinghurst, Sydney, NSW 2010, Australia
    • School of Medical Sciences, University of NSW, Sydney, NSW, Australia
  • ,
  • Yan-Chuan Shi

      Affiliations

    • Neuroscience Program, Garvan Institute of Medical Research, St. Vincent’s Hospital, 384 Victoria St., Darlinghurst, Sydney, NSW 2010, Australia
  • ,
  • Lei Zhang

      Affiliations

    • Neuroscience Program, Garvan Institute of Medical Research, St. Vincent’s Hospital, 384 Victoria St., Darlinghurst, Sydney, NSW 2010, Australia
  • ,
  • Aygul Aljanova

      Affiliations

    • Neuroscience Program, Garvan Institute of Medical Research, St. Vincent’s Hospital, 384 Victoria St., Darlinghurst, Sydney, NSW 2010, Australia
  • ,
  • Zhou Lin

      Affiliations

    • Neuroscience Program, Garvan Institute of Medical Research, St. Vincent’s Hospital, 384 Victoria St., Darlinghurst, Sydney, NSW 2010, Australia
  • ,
  • Amy D. Nguyen

      Affiliations

    • Neuroscience Program, Garvan Institute of Medical Research, St. Vincent’s Hospital, 384 Victoria St., Darlinghurst, Sydney, NSW 2010, Australia
  • ,
  • Herbert Herzog

      Affiliations

    • Neuroscience Program, Garvan Institute of Medical Research, St. Vincent’s Hospital, 384 Victoria St., Darlinghurst, Sydney, NSW 2010, Australia
    • Faculty of Medicine, University of NSW, Sydney, NSW, Australia
  • ,
  • Shu Lin

      Affiliations

    • Neuroscience Program, Garvan Institute of Medical Research, St. Vincent’s Hospital, 384 Victoria St., Darlinghurst, Sydney, NSW 2010, Australia
    • Corresponding Author InformationCorresponding author. Tel.: +61 2 9295 82 91; fax: +61 2 9295 82 81.

Received 27 October 2009 ,Accepted 7 January 2010.

References 

  1. Acuna-Goycolea C, Tamamaki N, Yanagawa Y, Obata K, van den Pol AN. Mechanisms of neuropeptide Y, peptide YY, and pancreatic polypeptide inhibition of identified green fluorescent protein-expressing GABA neurons in the hypothalamic neuroendocrine arcuate nucleus. J. Neurosci. 2005;25:7406–7419
  2. Adrian TE, Bloom SR, Bryant MG, Polak JM, Heitz PH, et al. Distribution and release of human pancreatic polypeptide. Gut. 1976;17:940–944
  3. Asakawa A, Inui A, Ueno N, Makino S, Fujino MA, et al. Urocortin reduces food intake and gastric emptying in lean and ob/ob obese mice. Gastroenterology. 1999;116:1287–1292
  4. Asakawa A, Inui A, Yuzuriha H, Ueno N, Katsuura G, et al. Characterization of the effects of pancreatic polypeptide in the regulation of energy balance. Gastroenterology. 2003;124:1325–1336
  5. Balasubramaniam A, Mullins DE, Lin S, Zhai W, Tao Z, et al. Neuropeptide Y (NPY) Y4 receptor selective agonists based on NPY(32–36): development of an anorectic Y4 receptor selective agonist with picomolar affinity. J. Med. Chem. 2006;49:2661–2665
  6. Batterham RL, Le Roux CW, Cohen MA, Park AJ, Ellis SM, et al. Pancreatic polypeptide reduces appetite and food intake in humans. J. Clin. Endocrinol. Metab. 2003;88:3989–3992
  7. Bernardis LL, Awad A, Fink C, Bellinger LL. Metabolic and neuroendocrine indices one month after lateral hypothalamic area lesions. Physiol. Behav. 1992;52:133–139
  8. Campbell RE, Smith MS, Allen SE, Grayson BE, Ffrench-Mullen JM, et al. Orexin neurons express a functional pancreatic polypeptide Y4 receptor. J. Neurosci. 2003;23:1487–1497
  9. Challis BG, Pinnock SB, Coll AP, Carter RN, Dickson SL, et al. Acute effects of PYY3-36 on food intake and hypothalamic neuropeptide expression in the mouse. Biochem. Biophys. Res. Commun. 2003;311:915–919
  10. Cowley MA, Smart JL, Rubinstein M, Cerdan MG, Diano S, et al. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature. 2001;411:480–484
  11. Decavel C, Van den Pol AN. GABA: a dominant neurotransmitter in the hypothalamus. J. Comput. Neurol. 1990;302:1019–1037
  12. Ganjavi HaS CM. Hypocretin/orexin: a molecular link between sleep, energy regulation, and pleasure. J. Neuropsychiatry Clin. Neurosci. 2007;19:413–419
  13. Haynes AC, Jackson B, Overend P, Buckingham RE, Wilson S, et al. Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat. Peptides. 1999;20:1099–1105
  14. Horvath TL, Naftolin F, Leranth C. GABAergic and catecholaminergic innervation of mediobasal hypothalamic beta-endorphin cells projecting to the medial preoptic area. Neuroscience. 1992;51:391–399
  15. Jegou S, Blasquez C, Delbende C, Bunel DT, Vaudry H. Regulation of alpha-melanocyte-stimulating hormone release from hypothalamic neurons. Ann. NY Acad. Sci. 1993;680:260–278
  16. Johnen H, Lin S, Kuffner T, Brown DA, Tsai VW, et al. Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1. Nat. Med. 2007;13:1333–1340
  17. King BM. The rise, fall, and resurrection of the ventromedial hypothalamus in the regulation of feeding behavior and body weight. Physiol. Behav. 2006;87:221–244
  18. Komori T, Morikawa Y, Tamura S, Doi A, Nanjo K, et al. Subcellular localization of glucose transporter 4 in the hypothalamic arcuate nucleus of ob/ob mice under basal conditions. Brain Res. 2005;1049:34–42
  19. Komori T, Morikawa Y, Nanjo K, Senba E. Induction of brain-derived neurotrophic factor by leptin in the ventromedial hypothalamus. Neuroscience. 2006;139:1107–1115
  20. Lin S, Shi Y, Yulyaningsih E, Aljanova A, Zhang L, Macia L, et al. Critical role of arcuate Y4 receptors and the melanocortin system in pancreatic polypeptide-induced reduction in food intake in mice. PLOS One. 2009;4:e8488
  21. McTigue DM, Hermann GE, Rogers RC. Effect of pancreatic polypeptide on rat dorsal vagal complex neurons. J. Physiol. 1997;499:475–483
  22. Parker R, Herzog H. Localization of Y-receptor subtype mRNAs in rat brain by digoxigenin labeled in situ hybridization. Neuropeptide Y Protocols. 2000;153:165–183
  23. Rodgers RJ, Ishii Y, Halford JC, Blundell JE. Orexins and appetite regulation. Neuropeptides. 2002;36:303–325
  24. Sainsbury A, Schwarzer C, Couzens M, Jenkins A, Oakes SR, et al. Y4 receptor knockout rescues fertility in ob/ob mice. Genes Develop. 2002;16:1077–1088
  25. Sainsbury A, Schwarzer C, Couzens M, Herzog H. Y2 receptor deletion attenuates the type 2 diabetic syndrome of ob/ob mice. Diabetes. 2002;51:3420–3427
  26. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998;92(4):573–585
  27. Tsuchida A, Nonomura T, Ono-Kishino M, Nakagawa T, Taiji M, et al. Acute effects of brain-derived neurotrophic factor on energy expenditure in obese diabetic mice. Int. J. Obes. Relat. Metab. Disord. 2001;25:1286–1293
  28. Ueno N, Inui A, Iwamoto M, Kaga T, Asakawa A, et al. Decreased food intake and body weight in pancreatic polypeptide-overexpressing mice. Gastroenterology. 1999;117:1427–1432
  29. Vergoni AV, Bertolini A. Role of melanocortins in the central control of feeding. Eur. J. Pharmacol. 2000;405:25–32
  30. Xu B, Goulding EH, Zang K, Cepoi D, Cone RD, et al. Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat. Neurosci. 2003;6:736–742

PII: S0143-4179(10)00005-3

doi: 10.1016/j.npep.2010.01.001

Neuropeptides
Volume 44, Issue 3 , Pages 261-268 , June 2010