Neuropeptides
Volume 44, Issue 3 , Pages 241-246 , June 2010

Wake promoting effects of cocaine and amphetamine-regulated transcript (CART)

  • Glenda L. Keating

      Affiliations

    • Department of Neurology, Emory University School of Medicine, Suite 6000, WMB, Atlanta, GA 30322, United States
    • Corresponding Author InformationCorresponding author. Tel.: +1 404 727 3305; fax: +1 404 727 3157.
  • ,
  • Michael J. Kuhar

      Affiliations

    • Neuroscience Division, Yerkes Primate Research Center of Emory University, 954 Gatewood Rd., NE, Atlanta, GA 30329, United States
  • ,
  • Donald L. Bliwise

      Affiliations

    • Department of Neurology, Emory University School of Medicine, Suite 6000, WMB, Atlanta, GA 30322, United States
  • ,
  • David B. Rye

      Affiliations

    • Department of Neurology, Emory University School of Medicine, Suite 6000, WMB, Atlanta, GA 30322, United States

Received 14 August 2009 ,Accepted 19 December 2009.

References 

  1. Adamantidis A, de Lecea L. Sleep and metabolism: shared circuits, new connections. Trends Endocrinol. Metab. 2008;19:362–370
  2. Broberger C, Holmberg K, Kuhar MJ, Hokfelt T. Cocaine- and amphetamine-regulated transcript in the rat vagus nerve: a putative mediator of cholecystokinin-induced satiety. Proc. Natl. Acad. Sci. USA. 1999;96:13506–13511
  3. Buckley TM, Schatzberg AF. On the interactions of the hypothalamic-pituitary-adrenal (HPA) axis and sleep: normal HPA axis activity and circadian rhythm, exemplary sleep disorders. J. Clin. Endocrinol. Metab. 2005;90:3106–3114
  4. Dallvechia-Adams S, Kuhar MJ, Smith Y. Cocaine- and amphetamine-regulated transcript peptide projections in the ventral midbrain: colocalization with gamma-aminobutyric acid, melanin-concentrating hormone, dynorphin, and synaptic interactions with dopamine neurons. J. Comp. Neurol. 2002;448:360–372
  5. Davidowa H, Li Y, Plagemann A. Altered responses to orexigenic (AGRP, MCH) and anorexigenic (alpha-MSH, CART) neuropeptides of paraventricular hypothalamic neurons in early postnatally overfed rats. Eur. J. Neurosci. 2003;18:613–621
  6. Douglass J, McKinzie AA, Couceyro P. PCR differential display identifies a rat brain mRNA that is transcriptionally regulated by cocaine and amphetamine. J. Neurosci. 1995;15:2471–2481
  7. Edgar DM, Seidel WF. Modafinil induces wakefulness without intensifying motor activity or subsequent rebound hypersomnolence in the rat. J. Pharmacol. Exp. Ther. 1997;283:757–769
  8. Elias CF, Lee CE, Kelly JF, Ahima RS, Kuhar M, Saper CB, et al. Characterization of CART neurons in the rat and human hypothalamus. J. Comp. Neurol. 2001;432:1–19
  9. Fort P, Bassetti CL, Luppi PH. Alternating vigilance states: new insights regarding neuronal networks and mechanisms. Eur. J. Neurosci. 2009;29:1741–1753
  10. Hagan JJ, Leslie RA, Patel S, Evans ML, Wattam TA, Holmes S, et al. Orexin A activates locus coeruleus cell firing and increases arousal in the rat. Proc. Natl. Acad. Sci. USA. 1999;96:10911–10916
  11. Hanriot L, Camargo N, Courau AC, Leger L, Luppi PH, Peyron C. Characterization of the melanin-concentrating hormone neurons activated during paradoxical sleep hypersomnia in rats. J. Comp. Neurol. 2007;505:147–157
  12. Keating GL, Kuhar MJ, Rye DB. High dose CART peptide induces abnormal EEG activity and behavioral seizures. Neuropeptides. 2008;42:199–204
  13. Kirouac GJ, Parsons MP, Li S. Innervation of the paraventricular nucleus of the thalamus from cocaine- and amphetamine-regulated transcript (CART) containing neurons of the hypothalamus. J. Comp. Neurol. 2006;497:155–165
  14. Koylu EO, Couceyro PR, Lambert PD, Kuhar MJ. Cocaine- and amphetamine-regulated transcript peptide immunohistochemical localization in the rat brain. J. Comp. Neurol. 1998;391:115–132
  15. Koylu E, Smith Y, Couceyro P, Kuhar M. CART peptides colocalize with tyrosine hydroxylase in rat locus coeruleus. Synapse. 1999;31:309–311
  16. Kuhar MJ, Adams LD, Hunter RG, Vechia SD, Smith Y. CART peptides. Regul. Pept. 2000;89:1–6
  17. Mignot E, Taheri S, Nishino S. Sleeping with the hypothalamus: emerging therapeutic targets for sleep disorders. Nature Neurosci. 2002;5(Suppl.):1071–1075
  18. Minzenberg MJ, Carter CS. Modafinil: a review of neurochemical actions and effects on cognition. Neuropsychopharmacology. 2008;33:1477–1502
  19. Murphy KG, Abbott CR, Mahmoudi M, Hunter R, Gardiner JV, Rossi M, et al. Quantification and synthesis of cocaine- and amphetamine-regulated transcript peptide (79–102)-like immunoreactivity and mRNA in rat tissues. J. Endocrinol. 2000;166:659–668
  20. Nishino S. The hypothalamic peptidegeric system, hypocetin/orexin and vigilance control. Neuropeptides. 2007;41:117–133
  21. Peyron C. Molecular characterization of hypocretin/orexin and MCH neurons: relevance to narcolepsy. In:  Basetti C,  Billard M,  Mignot E editor. Narcolepsy and Hypersomnia. New York: Marcel Dekker Inc.; 2006;
  22. Piper DC, Upton N, Smith MI, Hunter AJ. The novel brain neuropeptide, orexin-A, modulates the sleep-wake cycle of rats. Eur. J. Neurosci. 2000;12:726–730
  23. Rogge G, Jones D, Hubert W, Lin Y, Kuahr MJ. CART peptides: regulators of body weight, reward and other functions. Nature Rev.: Neurosci. 2008;9:747–758
  24. Rye D. The two faces of Eve: dopamine’s modulation of wakefulness and sleep. Neurology. 2004;63(Suppl. 3):S2–S7
  25. Scammell T. The neurobiology, diagnosis, and treatment of narcolepsy. Ann. Neurol. 2003;53:154–166
  26. Shieh KR, Yang SC. Effects of estradiol on the stimulation of dopamine turnover in mesolimbic and nigrostriatal systems by cocaine- and amphetamine-regulated transcript peptide in female rats. Neuroscience. 2008;154:1589–1597
  27. Smith Y, Kieval J, Couceyro PR, Kuhar MJ. CART peptide-immunoreactive neurones in the nucleus accumbens in monkeys: ultrastructural analysis, colocalization studies, and synaptic interactions with dopaminergic afferents. J. Comp. Neurol. 1999;407:491–511
  28. Smith SM, Vaughan JM, Donaldson CJ, Rivier J, Li C, Chen A, et al. Cocaine- and amphetamine-regulated transcript activates the hypothalamic-pituitary-adrenal axis through a corticotropin-releasing factor receptor-dependent mechanism. Endocrinology. 2004;145:5202–5209
  29. Stanek LM. Cocaine- and amphetamine related transcript (CART) and anxiety. Peptides. 2006;27:2005–2011
  30. Vicentic A. CART peptide diurnal variations in blood and brain. Peptides. 2006;27:1942–1948
  31. Vicentic A, Lakatos A, Jones D. The CART receptors: background and recent advances. Peptides. 2006;27:1934–1937
  32. Wisor J, Nishino S, Sora I, Uhl G, Mignot E, Edgar D. Dopaminergic role in stimulant-induced wakefulness. J. Neurosci. 2001;21:1787–1794
  33. Yang SC, Pan JT, Li HY. CART peptide increaces the mesolimbic dopaminergic neuronal activity: a microdialysis study. Eur. J. Pharmacol. 2004;494:179–182

 This research was supported by NIH NS055015, RR00165, DA00418 and DA10732.

PII: S0143-4179(09)00152-8

doi: 10.1016/j.npep.2009.12.013

Neuropeptides
Volume 44, Issue 3 , Pages 241-246 , June 2010