Neuropeptides
Volume 44, Issue 2 , Pages 155-161 , April 2010

Distribution and expression of B2-kinin receptor on human leukocyte subsets in young adults and elderly using flow cytometry

  • Benoit Bourdet

      Affiliations

    • Inserm, U 858, BP 84225, F-31432 Toulouse Cedex, France
    • Université de Toulouse, UPS, Institut de Médecine Moléculaire de Rangueil, IFR150, F-31432 Toulouse, France
    • CHU de Toulouse, F-31432 Toulouse, France
    • These authors contributed equally to this work.
    • ,
  • Christiane Pécher

      Affiliations

    • Inserm, U 858, BP 84225, F-31432 Toulouse Cedex, France
    • Université de Toulouse, UPS, Institut de Médecine Moléculaire de Rangueil, IFR150, F-31432 Toulouse, France
    • These authors contributed equally to this work.
    • ,
  • Vincent Minville

      Affiliations

    • Inserm, U 858, BP 84225, F-31432 Toulouse Cedex, France
    • Université de Toulouse, UPS, Institut de Médecine Moléculaire de Rangueil, IFR150, F-31432 Toulouse, France
    • CHU de Toulouse, F-31432 Toulouse, France
    • ,
  • Acil Jaafar

      Affiliations

    • Inserm, U 858, BP 84225, F-31432 Toulouse Cedex, France
    • Université de Toulouse, UPS, Institut de Médecine Moléculaire de Rangueil, IFR150, F-31432 Toulouse, France
    • CHU de Toulouse, F-31432 Toulouse, France
    • ,
  • Julien Allard

      Affiliations

    • Inserm, U 858, BP 84225, F-31432 Toulouse Cedex, France
    • Université de Toulouse, UPS, Institut de Médecine Moléculaire de Rangueil, IFR150, F-31432 Toulouse, France
    • CHU de Toulouse, F-31432 Toulouse, France
    • ,
  • Nelly Blaes

      Affiliations

    • Inserm, U 858, BP 84225, F-31432 Toulouse Cedex, France
    • Université de Toulouse, UPS, Institut de Médecine Moléculaire de Rangueil, IFR150, F-31432 Toulouse, France
    • ,
  • Jean-Pierre Girolami

      Affiliations

    • Inserm, U 858, BP 84225, F-31432 Toulouse Cedex, France
    • Université de Toulouse, UPS, Institut de Médecine Moléculaire de Rangueil, IFR150, F-31432 Toulouse, France
    • Corresponding Author InformationCorresponding author. Address: Inserm, U 858, BP 84225, F-31432 Toulouse Cedex, France. Tel.: +33 5 61322621.
    • ,
  • Ivan Tack

      Affiliations

    • Inserm, U 858, BP 84225, F-31432 Toulouse Cedex, France
    • Université de Toulouse, UPS, Institut de Médecine Moléculaire de Rangueil, IFR150, F-31432 Toulouse, France
    • CHU de Toulouse, F-31432 Toulouse, France

References 

  1. Bertram CM, Baltic S, Misso NL, Bhoola KD, Foster PS, Thompson PJ, et al. Expression of kinin B1 and B2 receptors in immature, monocyte-derived dendritic cells and bradykinin-mediated increase in intracellular Ca2+ and cell migration. J. Leukoc. Biol. 2007;81:1445–1454
  2. Bertram CM, Misso NL, Fogel-Petrovic M, Figueroa CD, Foster PS, Thompson PJ, et al. Expression of kinin receptors on eosinophils: comparison of asthmatic patients and healthy subjects. J. Leukoc. Biol. 2009;85:544–552
  3. Böckmann S, Paegelow I. Kinins and kinin receptors: importance for the activation of leukocytes. J. Leukoc. Biol. 2000;68:587–692
  4. Byrd JB, Touzin K, Sile S, Gainer JV, Yu C, Nadeau J, et al. Dipeptidyl peptidase IV in angiotensin-converting enzyme inhibitor associated angioedema. Hypertension. 2008;51:141–147
  5. Campos MM, Leal PC, Yunes RA, Calixto JB. Non-peptide antagonists for kinin B1 receptors: new insights into their therapeutic potential for the management of inflammation and pain. Trends Pharmacol. Sci. 2006;27:646–651
  6. Carretero OA, Scicli AG. Local hormonal factors (intracrine, autocrine, and paracrine) in hypertension. Hypertension. 1991;18(Suppl. 3):I58–I69
  7. Couture R, Girolami JP. Putative roles of kinin receptors in the therapeutic effects of angiotensin 1-converting enzyme inhibitors in diabetes mellitus. Eur. J. Pharmacol. 2004;500:467–485
  8. Dabek J, Wilczok T, Gasior Z, Kucia-Kuzma S, Twardowski R, Kulach A. Gene expression of kinin receptors B1 and B2 in PBMC from patients with cardiac syndrome X. Scand. Cardiovasc. 2007;41:391–396
  9. Dabek J, Kulach A, Smolka G, Wilczok T, Scieszka J, Gasior Z. Expression of genes encoding kinin receptors in peripheral blood mononuclear cells from patients with acute coronary syndromes. Intern. Med. J. 2008;38:892–896
  10. Dos Santos AC, Roffê E, Arantes RM, Juliano L, Pesquero JL, Pesquero JB, et al. Kinin B2 receptor regulates chemokines CCL2 and CCL5 expression and modulates leukocyte recruitment and pathology in experimental autoimmune encephalomyelitis (EAE) in mice. J. Neuroinflamm. 2008;5:49
  11. Gainer JV, Morrow JD, Loveland A, King DJ, Brown NJ. Effect of bradykinin-receptor blockade on the response to angiotensin-converting-enzyme inhibitor in normotensive and hypertensive subjects. N. Engl. J. Med. 1998;339:1285–1292
  12. Kakoki M, Smithies O. The kallikrein-kinin system in health and in diseases of the kidney. Kidney Int. 2009;75:1019–1030
  13. Kränkel N, Katare RG, Siragusa M, Barcelos LS, Campagnolo P, Mangialardi G, et al. Role of kinin B2 receptor signaling in the recruitment of circulating progenitor cells with neovascularization potential. Circ. Res. 2008;103:1335–1343
  14. Lonn E, Roccaforte R, Yi Q, Dagenais G, Sleight P, Bosch J, et al. Effect of long-term therapy with ramipril in high-risk women. J. Am. Coll. Cardiol. 2002;40:693–702
  15. Maddedu P, Anania V, Parpaglia PP, Demontis M, Varoni MV, Fattaccio MC, et al. Chronic kinin receptor blockade induces hypertension in deoxycorticosterone-treated rats. Brit. J. Pharmacol. 1993;108:651–657
  16. Marino F, Guasti L, Cosentino M, Rasini E, Ferrari M, Maio RC, et al. Simvastatin treatment in subjects at high cardiovascular risk modulates AT 1R expression on circulating monocytes and T lymphocytes. J. Hypertens. 2008;26:1147–1155
  17. Matthews KA, Meilahn E, Kuller LH, Kelsey SF, Caggiula AW, Wing RR. Menopause and risk factors for coronary heart disease. N. Engl. J. Med. 1989;7:641–646
  18. Moreau ME, Garbacki N, Molinaro G, Brown NJ, Marceau F, Adam A. The kallikrein-kinin system: current and future pharmacological targets. J. Pharmacol. Sci. 2005;99:6–38
  19. Pesquero JB, Bader M. Genetically altered animal models in the kallikrein-kinin system. Biol. Chem. 2006;387:119–126
  20. Pretorius M, Rosenbaum D, Vaughan DE, Brown NJ. Angiotensin-converting enzyme inhibition increases human vascular tissue-type plasminogen activator release through endogenous bradykinin. Circulation. 2003;107:579–585
  21. Pretorius M, Luther JM, Murphey LJ, Vaughan DE, Brown NJ. Angiotensin-converting enzyme inhibition increases basal vascular tissue plasminogen activator release in women but not in men. Arterioscler. Thromb. Vasc. Biol. 2005;25:2435–2440
  22. Pretorius MM, Gainer JV, Van Guilder GP, Coelho EB, Luther JM, Fong P, et al. The bradykinin type 2 receptor BE1 polymorphism and ethnicity influence systolic blood pressure and vascular resistance. Clin. Pharmacol. Ther. 2008;83:122–129
  23. Pretorius M, Van Guilder GP, Guzman RJ, Luther JM, Brown NJ. 17Beta-estradiol increases basal but not bradykinin-stimulated release of active t-PA in young postmenopausal women. Hypertension. 2008;51:1190–1196
  24. Rasini E, Cosentino M, Marino F, Legnaro M, Ferrari M, Guasti L, et al. Angiotensin II type 1 receptor expression on human leukocyte subsets: a flow cytometric and RT-PCR study. Regul. Pept. 2006;134:69–74
  25. Stewart JM. Bradykinin antagonists as anti-cancer agents. Curr. Pharm. Des. 2003;9:2036–2042
  26. Tschöpe C, Westermann D. Development of diabetic cardiomyopathy and the kallikrein-kinin system: new insights from B1 and B2 receptor signaling. Biol. Chem. 2008;389:707–711
  27. Van Guilder GP, Pretorius M, Luther JM, Byrd JB, Hill K, Gainer JV, et al. Bradykinin type 2 receptor BE1 genotype influences bradykinin-dependent vasodilation during angiotensin-converting enzyme inhibition. Hypertension. 2008;51:454–549

PII: S0143-4179(09)00144-9

doi: 10.1016/j.npep.2009.12.005

Neuropeptides
Volume 44, Issue 2 , Pages 155-161 , April 2010

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