Neuropeptides
Volume 44, Issue 2 , Pages 115-118 , April 2010

Structural analysis of three peptides related to the transmambranic helix VI of AT1 receptor

  • Samuel Marcos Ribeiro de Noronha

      Affiliations

    • Ginecologia Molecular/Ginecologia, UNIFESP-R. Pedro de Toledo, 791 – 4o. Andar, V. Clementino, CEP04039032 Sao Paulo, SP, Brazil
    • Corresponding Author InformationCorresponding author. Address: Molecular Gynecology Laboratory, Gynecology Department, Federal University of Sao Paulo, Rua Pedro de Toledo, 781 – 4th floor, Sao Paulo, 04039-032 SP, Brazil. Tel.: +55 55791534; fax: +55 11 55793321.
    • ,
  • Silvana Aparecida Alves Corrêa

      Affiliations

    • Ginecologia Molecular/Ginecologia, UNIFESP-R. Pedro de Toledo, 791 – 4o. Andar, V. Clementino, CEP04039032 Sao Paulo, SP, Brazil
    • ,
  • Erick Fernando Poletti

      Affiliations

    • Dep. Biofisica-R. Botucatu, 840 – 7o. Andar, V. Clementino, Sao Paulo, SP, Brazil
    • ,
  • Douglas Duarte Lopes

      Affiliations

    • Dep. Biofisica-R. Botucatu, 840 – 7o. Andar, V. Clementino, Sao Paulo, SP, Brazil
    • ,
  • Caroline Corrêa da Silva

      Affiliations

    • Dep. Biofisica-R. Botucatu, 840 – 7o. Andar, V. Clementino, Sao Paulo, SP, Brazil
    • ,
  • Mauricio Luis Sforça

      Affiliations

    • Laboratorio Nacional de Luz Sincroton-Rua Giuseppe Maximo Scolfaro, 10000-Polo II de Alta Tecnologia de Campinas-Campinas, SP, Brazil
    • ,
  • Suma Imura Shimuta

      Affiliations

    • Dep. Biofisica-R. Botucatu, 840 – 7o. Andar, V. Clementino, Sao Paulo, SP, Brazil
    • ,
  • Nilson Ivo Tonin Zanchin

      Affiliations

    • Laboratorio Nacional de Luz Sincroton-Rua Giuseppe Maximo Scolfaro, 10000-Polo II de Alta Tecnologia de Campinas-Campinas, SP, Brazil
    • ,
  • Clovis Ryuichi Nakaie

      Affiliations

    • Dep. Biofisica-R. Botucatu, 840 – 7o. Andar, V. Clementino, Sao Paulo, SP, Brazil
    • ,
  • Ismael Dale Cotrim Guerreiro da Silva

      Affiliations

    • Ginecologia Molecular/Ginecologia, UNIFESP-R. Pedro de Toledo, 791 – 4o. Andar, V. Clementino, CEP04039032 Sao Paulo, SP, Brazil

References 

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  2. Correa SAA, Zalcberg H, Han SW, Costa-Neto CM, Oliveira L, Paiva AM, et al. Aliphatic amino acids in helix VI of the AT(1) receptor play a relevant role in agonist binding and activity. Regul. Peptides. 2002;106:33–38
  3. Correa SAA, Pacheco NAS, Costa-Neto CM, Oliveira L, Pesquero JB, Han SW, et al. Angiotensin II AT1 receptor mutants expressed in CHO cells caused morphological change and inhibition of cell growth. Regul. Peptides. 2005;131:18–22
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  11. Marie J, Maigret B, Joseph M-P, Larguier R, Nouet S, Lombard C, et al. Tyr292 in the seventh transmembrane domain of the AT1A angiotensin II receptor is essential for its coupling to phospholipase C. J. Biol. Chem. 1994;269:20815–20818
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  15. Murphy TJ, Alexander RW, Griendling K, Runge MS, Bernstein KE. Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor. Nature. 1991;351:233–236
  16. Noda K, Saad Y, Kinoshita A, Boyle TP, Graham RM, Husain A, et al. Tetrazole and carboxylate groups of angiotensin II receptor antagonists bind to the same subsite by different mechanisms. J. Biol. Chem. 1995;270:2284–2289
  17. Noda K, Saad Y, Karnik SS. Interaction of Phe8 of angiotensin II with Lys199 and His256 of AT1 receptor in agonist activation. J. Biol. Chem. 1995;270:28511–28514
  18. Sasaki K, Yamano Y, Bardhan S, Iwai N, Murphy TJ, Hasegawa M, et al. Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptor. Nature. 1991;351:230–232
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☆ This manuscript is related to the The Fifth International Symposium on Peptide Receptors and Kinin 2009.

☆☆ Supported by Grants 2005/54160–2 and 2008/50776-7 from the Fundação de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)-Brazil.

PII: S0143-4179(09)00135-8

doi: 10.1016/j.npep.2009.11.006

Neuropeptides
Volume 44, Issue 2 , Pages 115-118 , April 2010

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