Neuropeptides
Volume 44, Issue 2 , Pages 107-113 , April 2010

Bradykinin B1 receptor antagonist R954 inhibits eosinophil activation/proliferation/migration and increases TGF-β and VEGF in a murine model of asthma

  • Luciana M.C. Vasquez-Pinto

      Affiliations

    • Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, Brazil
    • ,
  • François Nantel

      Affiliations

    • Institute of Pharmacology of Sherbrooke, University of Sherbrooke, Canada
    • ,
  • Pierre Sirois

      Affiliations

    • Institute of Pharmacology of Sherbrooke, University of Sherbrooke, Canada
    • ,
  • Sonia Jancar

      Affiliations

    • Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, Brazil
    • Corresponding Author InformationCorresponding author. Address: Departamento de Immunologia, ICB/USP, Avenida Professor Lineu Prestes, 1730, CEP: 05508-000 São Paulo, SP, Brazil. Tel./fax: +55 11 3091774.

References 

  1. Bartram U, Speer CP. The role of transforming growth factor beta in lung development and disease. Chest. 2004;125:754–765
  2. Bertram CM, Misso NL, Fogel-Petrovic M, Figueroa CD, Foster PS, Thompson PJ, et al. Expression of Kinin receptors on eosinophils: comparison of asthmatic patients and healthy subjects. J. Leukoc. Biol. 2009;85:544–552
  3. Bozza PT, Melo RC, Bandeira-Melo C. Leukocyte lipid bodies regulation and function: contribution to allergy and host defence. Pharmacol. Ther. 2007;113:30–49
  4. Chavakis E, Dimmeler S. Regulation of endothelial cell survival and apoptosis during angiogenesis. Arterioscler. Thromb. Vasc. Biol. 2002;22:887–893
  5. Chiappara G, Gagliardo R, Siena A, Bonsignore MR, Bousquet J, Bonsignore G, et al. Airway remodelling in the pathogenesis of asthma. Curr. Opin. Allergy Clin. Immunol. 2001;1:85–93
  6. Coker RK, Laurent GJ, Shahzeidi S, Hernadez-Rodriguez NA, Pantelidis P, du Bois RM, et al. Diverse cellular TGF-beta 1 and TGF-beta 3 gene expression in normal human and murine lung. Eur. Respir. J. 1996;9:2501–2507
  7. Farmer SG, Wilkins DE, Meeker SA, Seeds EA, Page CP. Effects of bradykinin receptor antagonists on antigen-induced respiratory distress, airway hyperresponsiveness and eosinophilia in guinea-pigs. Br. J. Pharmacol. 1992;107:653–659
  8. Fattouh R, Jordana M. TGF-beta, eosinopils and IL-13 in allergic airway remodeling: a critical appraisal with therapeutic considerations. Inflamm. Allergy Drug. Targets. 2008;7:224–236
  9. Ferrara N, Gerber HP, Le Couter J. The biology of VEGF and its receptors. Nat. Med. 2003;9:669–676
  10. Gabra BH, Berthiaume N, Sirois P, Nantel F, Battistini B. The kinin system mediates hyperalgesia through the inducible Bradykinin B1 receptor subtype: evidence in various experimental animal models of type 1 and type 2 diabetic neuropathy. Biol. Chem. 2006;387:127–143
  11. Heijink, I.H., Postma, D.S., Noordhoek, J.A., Broekema, M., Kapus, A., 2009. House dust mite-promoted epithelial-to-mesenchymal transition in human bronchial epithelium. Am. J. Respir. Cell Mol. Biol. (epub ahead of print).
  12. Horiuchi T, Weller PF. Expression of VEGF by human eosinophils: upregulation by granulocyte/macrophage colony stimulating factor and interleukin-5. Am. J. Respir. Cell Mol. Biol. 1997;17:70–77
  13. Hoshino M, Takahashi M, Aoike N. Expression of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin immunoreactivity in asthmatic airways and its relationship to angiogenesis. J. Allergy Clin. Immunol. 2001;107:295–301
  14. Kay AB, Phipps S, Robinson DS. A role for eosinophils in airway remodeling in asthma. Trends Immunol. 2004;25:477–482
  15. Khalil N, Bereznay O, Sporn M, Greenberg AH. Macrophage production of transforming growth factor beta and fibroblast collagen synthesis in chronic pulmonary inflammation. J. Exp. Med. 1989;170:727–737
  16. Kingston PA, Sinha S, David A, Castro MG, Lowestein PR, Heagerty AM. Adenovirus-mediated gene transfer of a secreted transforming growth factor-beta type II receptor inhibits luminal loss and constrictive remodeling after coronary angioplasty and enhances adventitial collagen deposition. Circulation. 2001;104:2595–2601
  17. Landgraf RG, Steil AA, Sirois P, Jancar S. Modulation of allergic and immune complex-induced lung inflammation by bradykinin receptor antagonists. Inflamm. Res. 2003;53:78–83
  18. Landgraf RG, Sirois P, Jancar S. Differential modulation of murine lung inflammation by bradykinin B1 and B2 selective receptor antagonists. Eur. J. Pharmacol. 2004;460:75–83
  19. Lee CG, Link H, Baluk P, Homer RJ, Chapoval S, Bhandari V, et al. Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Nat. Med. 2004;10:1095–1103
  20. Letterio JJ, Roberts AB. Regulation of immune responses by TGF-beta. Annu. Rev. Immunol. 1998;16:137–161
  21. Marceau F, Regoli D. Bradykinin receptor ligands: therapeutic perspectives. Nat. Rev. Drug. Discov. 2004;3:845–852
  22. Mauviel A. Transforming growth factor beta: a key mediator of fibrosis. Meth. Mol. Med. 2005;117:69–80
  23. Pasquale CP, Martins MA, Bozza PT, Silva PM, Faria-Neto HC, Pires AL, et al. Bradykinin induces eosinophil accumulation in the rat pleural cavity. Int. Arch. Allergy Appl. Immunol. 1991;95:244–247
  24. Perron MS, Gobeil F, Pelletier S, Regoli D, Sirois P. Involvement of bradykinin B1 and B2 receptors in pulmonary leukocyte accumulation induced by Sephadex beads in guinea pigs. Eur. J. Pharmacol. 1999;376:83–89
  25. Robinson DS, North J, Zeibecoglou K, Ying S, Meng Q, Rankin S, et al. Eosinophil development and bone marrow and tissue eosinophils in atopic asthma. Int. Arch. Allergy Immunol. 1999;118:89–100
  26. Salib, R.J., Howarth, P.H., 2009. Transforming growth factor-beta in allergic inflammatory disease of the upper airways: friend or foe? Clin. Exp. Allergy (epub ahead of print).
  27. Smith N, Broadley KJ. Optimisation of the sensitisation conditions for an ovalbumin challenge model of asthma. Int. Immunopharmacol. 2007;7:183–190
  28. Thomas, B.J., Lindsay, M., Dagher, H., Freezer, N.J., Ghildyal, R., Bardin, P.G., 2009. Transforming growth factor-beta enhances rhinovirus infection by diminishing early innate responses. Am. J. Respir. Cell Mol. Biol. (epub ahead of print).
  29. Woisin FE, Matsumoto T, Douglas GL, Paul W, Walley ET, Page CP. Effect of antagonists for NK2 and B2 receptors on antigen induced airway responses in allergic rabbits. Pulmon. Pharmacol. Ther. 2000;13:13–23

PII: S0143-4179(09)00130-9

doi: 10.1016/j.npep.2009.11.001

Neuropeptides
Volume 44, Issue 2 , Pages 107-113 , April 2010

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