Neuropeptides
Volume 44, Issue 1 , Pages 57-61, February 2010

Differential effects of substance P or hemokinin-1 on transient receptor potential channels, TRPV1, TRPA1 and TRPM8, in the rat

  • Rumi Naono-Nakayama

      Affiliations

    • Division of Neurobiology, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki 889-1692, Japan
    • JSPS Research Fellow, Chiyoda, Tokyo 102-8472, Japan
    • Corresponding Author InformationCorresponding author. Address: Division of Neurobiology, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki 889-1692, Japan. Tel.: +81 985 85 0992; fax: +81 985 85 7323.
    • ,
  • Natsuki Sunakawa

      Affiliations

    • Department of Oral and Maxillofacial Surgery, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki 889-1692, Japan
    • ,
  • Tetsuya Ikeda

      Affiliations

    • Division of Neurobiology, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki 889-1692, Japan
    • ,
  • Toshikazu Nishimori

      Affiliations

    • Division of Neurobiology, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki 889-1692, Japan

Received 12 August 2009; accepted 14 October 2009. published online 19 November 2009.

Abstract 

Two tachykinin peptides, substance P (SP) and hemokinin-1 (HK-1), and three transient receptor potential (TRP) channels, TRPV1, TRPA1 and TRPM8, are similarly localized in the spinal dorsal horn and dorsal root ganglion, suggesting that TRP channels may be related or modulated by these tachykinin peptides. Thus, to clarify whether the responses of TRP channels are modulated by SP or HK-1, the effects of pretreatment with SP or HK-1 on the induction of scratching behavior by TRP channel agonists were examined. Pretreatment with SP or HK-1 enhanced the induction of scratching behavior by resiniferatoxin, a TRPV1 agonist, whereas scratching behavior induced by menthol, a TRPM8 agonist, was suppressed by pretreatment with these peptides. On the other hand, pretreatment with SP, but not HK-1, suppressed the induction of scratching behavior by cinnamaldehyde, a TRPA1 agonist. Taken together, the present results indicate that SP or HK-1 differentially modulated the response of TRPV1, TRPA1 or TRPM8 channel.

Keywords: Substance P, Hemokinin-1, TRPV1, TRPA1, TRPM8, Scratching behavior, Intrathecal administration

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PII: S0143-4179(09)00111-5

doi:10.1016/j.npep.2009.10.002

Neuropeptides
Volume 44, Issue 1 , Pages 57-61, February 2010

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