Neuropeptides
Volume 44, Issue 2 , Pages 77-86 , April 2010

Neuropeptide Y receptor subtypes in the dorsal vagal complex under acute feeding adaptation in the adult rat

  • Stéphanie Mahaut

      Affiliations

    • Physiologie Neurovégétative, UMR 6231 CNRS, Université Aix-Marseille-3, Ave. Escadrille Normandie-Niemen, 13397 Marseille cedex 20, France
    • ,
  • Yvan Dumont

      Affiliations

    • Douglas Mental Health University Institute, Dept. of Psychiatry, McGill University, 6875 Boul. LaSalle, Verdun, Montréal, QC, Canada H4H 1R3
    • ,
  • Alain Fournier

      Affiliations

    • INRS-IAF, Université du Québec, 245 Boul. Hymus, Pointe-Claire, QC, Canada H9R 1G6
    • ,
  • Rémi Quirion

      Affiliations

    • Douglas Mental Health University Institute, Dept. of Psychiatry, McGill University, 6875 Boul. LaSalle, Verdun, Montréal, QC, Canada H4H 1R3
    • ,
  • Emmanuel Moyse

      Affiliations

    • Physiologie Neurovégétative, UMR 6231 CNRS, Université Aix-Marseille-3, Ave. Escadrille Normandie-Niemen, 13397 Marseille cedex 20, France
    • Douglas Mental Health University Institute, Dept. of Psychiatry, McGill University, 6875 Boul. LaSalle, Verdun, Montréal, QC, Canada H4H 1R3
    • Corresponding Author InformationCorresponding author. Address: Physiologie Neurovégétative, UMR 6231 CNRS, Université Aix-Marseille-3, Ave. Escadrille Normandie-Niemen, 13397 Marseille cedex 20, France. Tel.: +33 4 91 28 84 53; fax: +33 4 91 28 88 85.

References 

  1. Adrian TE, Allen JM, Bloom SR, Ghatei MA, Rossor MN, Roberts GW, et al. Neuropeptide Y distribution in human brain. Nature. 1983;306:584–586
  2. Adrian TE, Ferri GL, Bacarese-Hamilton AJ, Fuessl HS, Polak JM, Bloom SR. Human distribution and release of a putative new gut hormone, peptide YY. Gastroenterology. 1985;89:1070–1077
  3. Allen YS, Adrian TE, Allen JM, Tatemoto K, Crow TJ, Bloom SR, et al. Neuropeptide Y distribution in the rat brain. Science. 1983;221:877–879
  4. Baranowska B, Chmielowska M, Wolinska-Witort E, Roguski K, Wasilewska-Dziubinska E. The relationship between neuropeptides and hormones in starvation. Neuroendocrinol. Lett. 2001;22:349–355
  5. Barsh GS, Schwartz MW. Genetic approaches to studying energy balance: perception and integration. Nat. Rev. Genet. 2002;3:589–600
  6. Batterham RL, Bloom SR. The gut hormone peptide YY regulates appetite. Ann. NY Acad. Sci. 2003;994:162–168
  7. Batterham RL, Cowley MA, Small CJ, Herzog H, Cohen MA, Dakin CL, et al. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature. 2002;418:650–654
  8. Batterham RL, Cohen MA, Ellis SM, Le Roux CW, Withers DJ, Frost GS, et al. Inhibition of food intake in obese subjects by peptide YY3-36. N. Engl. J. Med. 2003;349:941–948
  9. Batterham RL, Le Roux CW, Cohen MA, Park AJ, Ellis SM, Patterson M, et al. Pancreatic polypeptide reduces appetite and food intake in humans. J. Clin. Endocrinol. Metab. 2003;88:3989–3992
  10. Berthoud HR. Vagal and hormonal gut–brain communication: from satiation to satisfaction. Neurogastroenterol. Motil. 2008;20(Suppl. 1):64–72
  11. Bi S, Robinson BM, Moran TH. Acute food deprivation and chronic food restriction differentially affect hypothalamic NPY mRNA expression. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2003;285:R1030–R1036
  12. Blessing WW. The Lower Brainstem and Bodily Homeostasis. New York: Oxford University Press; 1997;
  13. Broberger C. Brain regulation of food intake and appetite: molecules and networks. J. Intern. Med. 2005;258:301–327
  14. Browning KN, Travagli RA. Neuropeptide Y and peptide YY inhibit excitatory synaptic transmission in the rat dorsal motor nucleus of the vagus. J. Physiol. 2003;549:775–785
  15. Browning KN, Coleman FH, Travagli RA. Effects of pancreatic polypeptide on pancreas-projecting rat dorsal motor nucleus of the vagus neurons. Am. J. Physiol. Gastrointest. Liver Physiol. 2005;289:G209–G219
  16. Cabrele C, Langer M, Bader R, Wieland HA, Doods HN, Zerbe O, et al. The first selective agonist for the neuropeptide Y Y5 receptor increases food intake in rats. J. Biol. Chem. 2000;275:36043–36048
  17. Cheng X, Broberger C, Tong Y, Yongtao X, Ju G, Zhang X, et al. Regulation of expression of neuropeptide Y Y1 and Y2 receptors in the arcuate nucleus of fasted rats. Brain Res. 1998;792:89–96
  18. Chua SC, Leibel RL, Hirsch J. Food deprivation and age modulate neuropeptide gene expression in the murine hypothalamus and adrenal gland. Mol. Brain Res. 1991;9:95–101
  19. Dumont Y, Martel JC, Fournier A, St Pierre S, Quirion R. Neuropeptide Y and neuropeptide Y receptor subtypes in brain and peripheral tissues. Prog. Neurobiol. 1992;38:125–167
  20. Dumont Y, Fournier A, Quirion R. Expression and characterization of the neuropeptide Y Y5 receptor subtype in the rat brain. J. Neurosci. 1998;18:5565–5574
  21. Dumont Y, Jacques D, St Pierre JA, Tong Y, Parker R, Herzog H, et al. Neuropeptide Y, peptide YY and pancreatic polypeptide receptor proteins and mRNAs in mammalian brains. In:  Quirion R,  Bjorklund A,  Hokfelt T editor. Handbook of Chemical Neuroanatomy. Peptide Receptors, Part 1. vol. 16:London, UK: Elsevier; 2000;p. 375–475
  22. Dumont Y, Redrobe JP, Quirion R. Neuropeptide Y receptors. In:  Pangalos MN,  Davies CH editor. Understanding G Protein-coupled Receptors and their Role in the CNS. Oxford, UK: Oxford University Press; 2002;p. 372–401
  23. Dumont Y, Moyse E, Fournier A, Quirion R. Evidence for the existence of an additional class of neuropeptide Y receptor sites in the rat brain. J. Pharmacol. Exp. Ther. 2005;315:99–108
  24. Dumont Y, Moyse E, Fournier A, Quirion R. Distribution of peripherally injected peptide YY ([125I]PYY (3-36)) and pancreatic polypeptide ([125I]hPP) in the CNS: enrichment in the area postrema. J. Mol. Neurosci. 2007;33:294–304
  25. Forest M, Martel JC, St Pierre S, Quirion R, Fournier A. Structural study of the N-terminal segment of neuropeptide tyrosine. J. Med. Chem. 1990;33:1615–1619
  26. Fry M, Ferguson AV. The sensory circumventricular organs: brain targets for circulating signals controlling ingestive behavior. Physiol. Behav. 2007;91:413–423
  27. Fry M, Hoyda TD, Ferguson AV. Making sense of it: roles of the sensory circumventricular organs in feeding and regulation of energy homeostasis. Exp. Biol. Med. (Maywood). 2007;232:14–26
  28. Gayle D, Ilyin SE, Plata-Salaman CR. Feeding status and bacterial LPS-induced cytokine and neuropeptide gene expression in hypothalamus. Am. J. Physiol. Regul. Integr. Comp. Physiol. 1999;277:R1188–R1195
  29. Grill HJ. Distributed neural control of energy balance: contributions from hindbrain and hypothalamus. Obesity (Silver Spring). 2006;14(Suppl. 5):216S–221S
  30. Grill HJ, Hayes MR. The nucleus tractus solitarius: a portal for visceral afferent signal processing, energy status assessment and integration of their combined effects on food intake. Int. J. Obes. (London). 2009;33(Suppl. 1):S11–S15
  31. Grove KL, Chen P, Koegler FH, Schiffmaker A, Susan SM, Cameron JL. Fasting activates neuropeptide Y neurons in the arcuate nucleus and the paraventricular nucleus in the rhesus macaque. Mol. Brain. Res. 2003;113:133–138
  32. Hoyda TD, Smith PM, Ferguson AV. Gastrointestinal hormone actions in the central regulation of energy metabolism: potential sensory roles for the circumventricular organs. Int. J. Obes. (London). 2009;(Suppl. 1):S16–S21
  33. Huo L, Grill HJ, Bjorbaek C. Divergent regulation of proopiomelanocortin neurons by leptin in the nucleus of the solitary tract and in the arcuate hypothalamic nucleus. Diabetes. 2006;55:567–573
  34. Inui A. Neuropeptide Y feeding receptors: are multiple subtypes involved?. Trends Pharmacol. Sci. 1999;20:43–46
  35. Jesudason DR, Monteiro MP, McGowan BM, Neary NM, Park AJ, Philippou E, et al. Low-dose pancreatic polypeptide inhibits food intake in man. Br. J. Nutr. 2007;97:426–429
  36. Kalia M, Fuxe K. Rat medulla oblongata. I. Cytoarchitectonic considerations. J. Comp. Neurol. 1985;233:285–307
  37. Kalia M, Sullivan JM. Brainstem projections of sensory and motor components of the vagus nerve in the rat. J. Comp. Neurol. 1982;211:248–265
  38. Kalra SP, Kalra PS. Neuropeptide Y: a conductor of the appetite-regulating orchestra in the hypothalamus. In:  Kastin AJ editors. Handbook of Biologically Active Peptides. San Diego, USA: Academic Press; 2006;p. 889–894
  39. Kamiji MM, Inui A. Neuropeptide Y receptor selective ligands in the treatment of obesity. Endocr. Rev. 2007;28:664–684
  40. Kanatani A, Ito J, Ishihara A, Iwaasa H, Fukuroda T, Fukami T, et al. NPY-induced feeding involves the action of a Y1-like receptor in rodents. Regul. Pept. 1998;75–76:409–415
  41. Kim YW, Kim KH, Ahn DK, Kim HS, Kim JY, Lee DC, et al. Time-course changes of hormones and cytokines by lipopolysaccharide and its relation with anorexia. J. Physiol. Sci. 2007;57:159–165
  42. Liu YL, Semjonous NM, Murphy KG, Ghatei MA, Bloom SR. The effects of pancreatic polypeptide on locomotor activity and food intake in mice. Int. J. Obes. (London). 2008;32:1712–1715
  43. Maley BE. Immunohistochemical localization of neuropeptides and neurotransmitters in the nucleus solitarius. Chem. Sens. 1996;21:367–376
  44. Michel MC, Beck-Sickinger A, Cox H, Doods HN, Herzog H, Larhammar D, et al. XVI international union of pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol. Rev. 1998;50:143–150
  45. Neary NM, McGowan BM, Monteiro MP, Jesudason DR, Ghatei MA, Bloom SR. No evidence of an additive inhibitory feeding effect following PP and PYY 3-36 administration. Int. J. Obes. (London). 2008;32:1438–1440
  46. Price CJ, Hoyda TD, Ferguson AV. The area postrema: a brain monitor and integrator of systemic autonomic state. Neuroscientist. 2008;14:182–194
  47. Schwartz GJ. Integrative capacity of the caudal brainstem in the control of food intake. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 2006;361:1275–1280
  48. Schwartz MW. Central nervous system regulation of food intake. Obesity (Silver Spring). 2006;14(Suppl. 1):1S–8S
  49. Schwartz MW, Woods SC, Porte D, Seeley RJ, Baskin DG. Central nervous system control of food intake. Nature. 2000;404:661–671
  50. Stanley BG, Kyrkouli SE, Lampert S, Leibowitz SF. Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity. Peptides. 1986;7:1189–1192
  51. Stanley BG, Anderson KC, Grayson MH, Leibowitz SF. Repeated hypothalamic stimulation with neuropeptide Y increases daily carbohydrate and fat intake and body weight gain in female rats. Physiol. Behav. 1989;46:173–177
  52. Stanley S, Wynne K, Bloom S. Gastrointestinal satiety signals III. Glucagon-like peptide 1, oxyntomodulin, peptide YY, and pancreatic polypeptide. Am. J. Physiol. Gastrointest. Liver Physiol. 2004;286:G693–G697
  53. Tatemoto K, Carlquist M, Mutt V. Neuropeptide Y – a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide. Nature. 1982;296:659–660
  54. Tovar SA, Seoane LM, Caminos JE, Nogueiras R, Casanueva FF, Dieguez C. Regulation of peptide YY levels by age, hormonal, and nutritional status. Obes. Res. 2004;12:1944–1950
  55. Track NS, McLeod RS, Mee AV. Human pancreatic polypeptide: studies of fasting and postprandial plasma concentrations. Can. J. Physiol. Pharmacol. 1980;58:1484–1489
  56. Whitcomb DC, Taylor IL, Vigna SR. Characterization of saturable binding sites for circulating pancreatic polypeptide in rat brain. Am. J. Physiol. Gastrointest. Liver Physiol. 1990;259:G687–G691

PII: S0143-4179(09)00110-3

doi: 10.1016/j.npep.2009.10.001

Neuropeptides
Volume 44, Issue 2 , Pages 77-86 , April 2010

Article Tools

* Image Usage & Resolution