Neuropeptides
Volume 44, Issue 1 , Pages 1-7 , February 2010

The regulatory role of neurotensin on the hypothalamic–anterior pituitary axons: Emphasis on the control of thyroid-related functions

Received 29 June 2009 ,Accepted 30 September 2009.

References 

  1. Alexander MJ. Estrogen-regulated synthesis of neurotensin in neurosecretory cells of the hypothalamic arcuate nucleus in the female rat. Endocrinology. 1993;133:1809–1816
  2. Antonelli T, Ferraro L, Fuxe K, Finetti S, Fournier J, Tanganelli S, et al. Neurotensin enhances endogenous extracellular glutamate levels in primary cultures of rat cortical neurons: involvement of neurotensin receptor in NMDA induced excitotoxicity. Cereb. Cortex. 2004;14:466–473
  3. Askew RD, Ramsden DB, Sheppard MC. The effect of neurotensin on pituitary secretion of thyrotrophin and prolactin in vitro. Acta Endocrinol. (Copenh.). 1984;105:156–160
  4. Bachelet CM, Scarcériaux V, Rostène W, Pélaprat D. Evidence for neurotensin autoreceptors and relationship of neurotensin and its receptors with tyrosine hydroxylase-positive neurons in rat primary hypothalamic cultures. Eur. J. Neurosci. 1997;9:1483–1487
  5. Bartolak-Suki E, Alexander MJ, Leeman SE. Estrogen reduces expression of neurotensin receptor mRNA in the suprachiasmatic nucleus of the female rat. Abstr. Soc. Neurosci. 1994;20:92
  6. Bauer B, Ehinger B, Tornqvist K, Waga J. Neurotransmitter release by certain neuropeptides in the chicken retina. Acta Ophthalmol. (Copenh.). 1985;63:581–587
  7. Bayer VE, Towle AC, Pickel VM. Vesicular and cytoplasmic localization of neurotensin-like immunoreactivity (NTLI) in neurons postsynaptic to terminals containing NTLI and/or tyrosine hydroxylase in the rat central nucleus of the amygdala. J. Neurosci. Res. 1991;30:398–413
  8. Bello AR, Dubourg P, Kah O, Tramu G. Identification of neurotensin-immunoreactive cells in the anterior pituitary of normal and castrated rats. A double immunocytochemical investigation at the light- and electron-microscopic levels. Neuroendocrinology. 1992;55:714–723
  9. Bello AR, Hernández G, González M, Reyes R, Negrín I, Marrero A, et al. Immunoreactive neurotensin in gonadotrophs and thyrotrophs is regulated by sex steroid hormones in the female rat. J. Neuroendocrinol. 1999;11:785–794
  10. Bello AR, Reyes R, Hernández G, Negrín I, González M, Tramu G, et al. Developmental expression of neurotensin in thyrotropes and gonadotropes of male and female rats. Neuroendocrinology. 2004;79:90–99
  11. Belmeguenai A, Desrues L, Leprince J, Vaudry H, Tonon MC, Louiset E. Neurotensin stimulates both calcium mobilization from inositol trisphosphate-sensitive intracellular stores and calcium influx through membrane channels in frog pituitary melanotrophs. Endocrinology. 2003;144:5556–5567
  12. Belmeguenai A, Leprince J, Tonon MC, Vaudry H, Louiset E. Neurotensin modulates the amplitude and frequency of voltage-activated Ca2+ currents in frog pituitary melanotrophs: implication of the inositol triphosphate/protein kinase C pathway. Eur. J. Neurosci. 2002;16:1907–1916
  13. Binder EB, Kinkead B, Owens MJ, Kilts CD, Nemeroff CB. Enhanced neurotensin neurotransmission is involved in the clinically relevant behavioral effects of antipsychotic drugs: evidence from animal models of sensorimotor gating. J. Neurosci. 2001;21:601–608
  14. Binder EB, Kinkead B, Owens MJ, Nemeroff CB. Neurotensin and dopamine interactions. Pharmacol. Rev. 2001;53:453–486
  15. Bissette G, Luttinger D, Mason GA, Hernandez DE, Loosen PT. Neurotensin and thermoregulation. Ann. N.Y. Acad. Sci. 1982;400:268–282
  16. Blackburn AM, Fletcher DR, Adrian TE, Bloom SR. Neurotensin infusion in man: pharmacokinetics and effect on gastrointestinal and pituitary hormones. J. Clin. Endocrinol. Metab. 1980;51:1257–1261
  17. Botto JM, Chabry J, Nouel D, Paquet M, Séguéla P, Vincent JP, et al. Identification in the rat neurotensin receptor of amino-acid residues critical for the binding of neurotensin. Brain Res. Mol. Brain Res. 1997;46:311–317
  18. Boudin H, Pelaprat D, Rostene W, Beaudet A. Cellular distribution of neurotensin receptors in rat brain: immunohistochemical study using an antipeptide antibody against the cloned high affinity receptor. J. Comp. Neurol. 1996;373:76–89
  19. Brown DR, Miller RJ. Neurotensin. Br. Med. Bull. 1982;38:239–245
  20. Cáceda R, Kinkead B, Nemeroff CB. Neurotensin: role in psychiatric and neurological diseases. Peptides. 2006;27:2385–2404
  21. Carraway RE, Leeman SE. Discovery of neurotensin. J. Biol. Chem. 1973;248:6845–6861
  22. Chabry J, Botto JM, Nouel D, Beaudet A, Vincent JP, Mazella J. Thr-422 and Tyr-424 residues in the carboxyl terminus are critical for the internalization of the rat neurotensin receptor. J. Biol. Chem. 1995;270:2439–2442
  23. Checler F. The prepro-neurotensin/neuromedin N gene: structural organization, regulation of expression and post-transcriptional events. In:  Turner AJ editors. Frontiers in Neurobiology: Neuropeptide Gene Expression. Portland: Portland Press; 1994;p. 133–160
  24. Ciofi P, Crowley WR, Pillez A, Schmued LL, Tramu G, Mazzuca M. Plasticity in expression of immunoreactivity for neuropeptide Y, enkephalins and neurotensin in the hypothalamic tubero-infundibular dopaminergic system during lactation in mice. J. Neuroendocrinol. 1993;5:599–602
  25. Cuber JC, Philippe C, Abello J, Corring T, Levenez F, Chayvialle JA. Plasma neurotensin in the conscious pig: release by individual food components and effects on exocrine pancreas secretion. Pancreas. 1990;5:306–313
  26. Dakka T, Cuber JC, Chayvialle JA. Functional coupling between the active transport of glucose and the secretion of intestinal neurotensin in rats. J. Physiol. 1993;469:753–765
  27. Evers BM. Neurotensin and growth of normal and neoplastic tissues. Peptides. 2006;27:2424–2433
  28. Ferraro L, Tomasini MC, Fernandez M, Bebe BW, O’Connor WT, Fuxe K, et al. Nigral neurotensin receptor regulation of nigral glutamate and nigroventral thalamic GABA transmission: a dual-probe microdialysis study in intact conscious rat brain. Neuroscience. 2001;102:113–120
  29. Goedert M, Lightman SL, Mantyh PW, Hunt SP, Emson PC. Neurotensin-like immunoreactivity and neurotensin receptors in the rat hypothalamus and in the neurointermediate lobe of the pituitary gland. Brain Res. 1985;358:59–69
  30. Goedert M, Lightman SL, Nagy JI, Marley PD, Emson PC. Neurotensin in the rat anterior pituitary gland. Nature. 1982;298:163–165
  31. Gui X, Carraway RE. Involvement of mast cells in basal and neurotensin-induced intestinal absorption of taurocholate in rats. Am. J. Physiol. Gastrointest. Liver Physiol. 2004;287:G408–G416
  32. Gui X, Dobner PR, Carraway RE. Endogenous neurotensin facilitates enterohepatic bile acid circulation by enhancing intestinal uptake in rats. Am. J. Physiol. Gastrointest. Liver Physiol. 2001;281:G1413–G1422
  33. Hellström PM, Nylander G, Rosell S. Effects of neurotensin on the transit of gastrointestinal contents in the rat. Acta Physiol. Scand. 1982;115:239–243
  34. Hernandez DE, Nemeroff CB, Valderrama MH, Prange AJ. Neurotensin-induced antinociception and hypothermia in mice. antagonism by TRH and structural analogs of TRH. Regul. Pept. 1984;8:41–49
  35. Horváth S, Palkovits M, Görcs T, Arimura A. Electron microscopic immunocytochemical evidence for the existence of bidirectional synaptic connections between growth hormone-releasing hormone- and somatostatin-containing neurons in the hypothalamus of the rat. Brain Res. 1989;481:8–15
  36. Jones PM, Ghatei MA, Steel J, O’Halloran D, Gon G, Legon S, et al. Evidence for neuropeptide Y synthesis in the rat anterior pituitary and the influence of thyroid hormone status: comparison with vasoactive intestinal peptide, substance P, and neurotensin. Endocrinology. 1989;125:334–341
  37. Kiss A, Palkovits M, Antoni FA, Eskay RL, Skirboll LR. Neurotensin in the rat median eminence. the possible sources of neurotensin-like fibers and varicosities in the external layer. Brain Res. 1987;416:129–135
  38. Kitabgi P, De Nadai F, Cuber JC, Dubuc I, Nouel D, Costentin J. Calcium-dependent release of neuromedin N and neurotensin from mouse hypothalamus. Neuropeptides. 1990;15:111–114
  39. Krassas GE. Appetite, adiposity, and thyroid function. Thyroid. 2007;17:411–412
  40. Leeman SE, Carraway RE. Neurotensin: discovery, isolation, characterization, synthesis and possible physiological roles. Ann. N.Y. Acad. Sci. 1982;400:1–16
  41. Li AH, Yeh TH, Tan PP, Hwang HM, Wang HL. Neurotensin excitation of serotonergic neurons in the rat nucleus raphe magnus: ionic and molecular mechanisms. Neuropharmacology. 2001;40:1073–1083
  42. Li S, Geiger JD, Lei S. Neurotensin enhances GABAergic activity in rat hippocampus CA1 region by modulating L-type calcium channels. J. Neurophysiol. 2008;99:2134–2143
  43. Li XM, Ferraro L, Tanganelli S, O’Connor WT, Hasselrot U, Ungerstedt U, et al. Neurotensin peptides antagonistically regulate postsynaptic dopamine D2 receptors in rat nucleus accumbens: a receptor binding and microdialysis study. J. Neural. Transm. Gen. Sect. 1995;102:125–137
  44. Martin S, Botto JM, Vincent JP, Mazella J. Pivotal role of an aspartate residue in sodium sensitivity and coupling to G proteins of neurotensin receptors. Mol. Pharmacol. 1999;55:210–215
  45. Mazella J, Botto JM, Guillemare E, Coppola T, Sarret P, Vincent JP. Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain. J. Neurosci. 1996;16:5613–5620
  46. McCann SM, Vijayan E, Koenig J, Krulich L. The effects of neurotensin on anterior pituitary hormone secretion. Ann. N.Y. Acad. Sci. 1982;400:160–171
  47. Memo M, Castelletti L, Valerio A, Missale C, Spano PF. Identification of neurotensin receptors associated with calcium channels and prolactin release in rat pituitary. J. Neurochem. 1986;47:1682–1688
  48. Merchenthaler I, Lennard DE. The hypophysiotropic neurotensin-immunoreactive neuronal system of the rat brain. Endocrinology. 1991;129:2875–2880
  49. Mercuri NB, Stratta F, Calabresi P, Bernardi G. Neurotensin induces an inward current in rat mesencephalic dopaminergic neurons. Neurosci. Lett. 1993;153:192–196
  50. Moyse E, Miller MM, Rostène W, Beaudet A. Effects of ovariectomy and estradiol replacement on the binding of 125I-neurotensin in rat suprachiasmatic nucleus. Neuroendocrinology. 1988;48:53–60
  51. Nemeroff CB, Bissette G, Manberg PJ, Osbahr AJ, Breese GR, Prange AJ. Neurotensin-induced hypothermia: evidence for an interaction with dopaminergic systems and the hypothalamic–pituitary–thyroid axis. Brain Res. 1980;195:69–84
  52. Nicot A, Rostène W, Bérod A. Hypercorticism induces neurotensin mRNA in rat periventricular hypothalamus. Neuroreport. 1995;6:2158–2160
  53. Nicot A, Rostene W, Berod A. Neurotensin receptor expression in the rat forebrain and midbrain: a combined analysis by in situ hybridization and receptor autoradiography. J. Comp. Neurol. 1994;341:407–419
  54. Niimi M, Takahara J, Sato M, Kawanishi K. Neurotensin and growth hormone-releasing factor-containing neurons projecting to the median eminence of the rat: a combined retrograde tracing and immunohistochemical study. Neurosci. Lett. 1991;133:183–186
  55. O’Connor WT, Tanganelli S, Ungerstedt U, Fuxe K. The effects of neurotensin on GABA and acetylcholine release in the dorsal striatum of the rat: an in vivo microdialysis study. Brain Res. 1992;573:209–216
  56. O’Halloran DJ, Jones PM, Ghatei MA, Domin J, Bloom SR. The regulation of neuropeptide expression in rat anterior pituitary following chronic manipulation of estrogen status: a comparison between substance P, neuropeptide Y, neurotensin, and vasoactive intestinal peptide. Endocrinology. 1990;127:1463–1469
  57. Pan JT, Tian Y, Lookingland KJ, Moore KE. Neurotensin-induced activation of hypothalamic dopaminergic neurons is accompanied by a decrease in pituitary secretion of prolactin and alpha-melanocyte-stimulating hormone. Life Sci. 1992;50:2011–2017
  58. Peric-Golia, L., Gardner, C.F., Peric-Golia, M., 1982–1983. Effect of neurotensin on specific activity of plasma cholesterol following intravenous administration of cholesterol-4-14C. Endocr. Res. Commun. 9, 179–184.
  59. Petersen CM, Nielsen MS, Nykjaer A, Jacobsen L, Tommerup N, Rasmussen HH, et al. Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography. J. Biol. Chem. 1997;272:3599–3605
  60. Petrie KA, Schmidt D, Bubser M, Fadel J, Carraway RE, Deutch AY. Neurotensin activates GABAergic interneurons in the prefrontal cortex. J. Neurosci. 2005;25:1629–1636
  61. Pettibone DJ, Hess JF, Hey PJ, Jacobson MA, Leviten M, Lis EV, et al. The effects of deleting the mouse neurotensin receptor NTR1 on central and peripheral responses to neurotensin. J. Pharmacol. Exp. Ther. 2002;300:305–313
  62. Pu S, Terasawa E. Effects of neurotensin and atrial natriuretic peptide on the in vivo release of luteinizing hormone-releasing hormone in the stalk-median eminence in ovariectomized female rhesus monkeys. Abstr. Soc. Neurosci. 1993;19:619
  63. Reinecke M. Neurotensin. Immunohistochemical localization in central and peripheral nervous system and in endocrine cells and its functional role as neurotransmitter and endocrine hormone. Prog. Histochem. Cytochem. 1985;16:1–172
  64. Rondeel JM, de Greef WJ, Visser TJ, Voogt JL. Effect of suckling on the in vivo release of thyrotropin-releasing hormone, dopamine and adrenaline in the lactating rat. Neuroendocrinology. 1988;48:93–96
  65. Rostène WH, Alexander MJ. Neurotensin and neuroendocrine regulation. Front. Neuroendocrinol. 1997;18:115–173
  66. Rowe WB, Nicot A, Sharma S, Gully D, Walker CD, Rostène WH, et al. Central administration of the neurotensin receptor antagonist, SR48692, modulates diurnal and stress-related hypothalamic–pituitary–adrenal activity. Neuroendocrinology. 1997;66:75–85
  67. Sahu A. Evidence suggesting that galanin (GAL), melanin-concentrating hormone (MCH), neurotensin (NT), proopiomelanocortin (POMC) and neuropeptide Y (NPY) are targets of leptin signaling in the hypothalamus. Endocrinology. 1998;139:795–798
  68. Sanz B, Exposito I, Mora F. Effects of neurotensin on the release of glutamic acid in the prefrontal cortex and striatum of the rat. Neuroreport. 1993;4:1194–1196
  69. Schimpff RM, Gourmelen M, Scarcériaux V, Lhiaubet AM, Rostène W. Plasma neurotensin levels in humans: relation to hormone levels in diseases involving the hypothalamo–pituitary–thyroid axis. Eur. J. Endocrinol. 1995;133:534–538
  70. Sheppard MC, Askew RD, Shennan KI, Franks S, Ramsden DB. Neurotensin regulation of TSH secretion in the rat. Biochem. Biophys. Res. Commun. 1983;113:248–254
  71. Sheppard MC, Shennan KI. The effect of thyroid hormones in vitro and in vivo on hypothalamic neurotensin release and content. Endocrinology. 1983;112:1996–1998
  72. Simerly RB, Swanson LW. Projections of the medial preoptic nucleus: a Phaseolus vulgaris leucoagglutinin anterograde tract-tracing study in the rat. J. Comp. Neurol. 1988;270:209–242
  73. St-Gelais F, Jomphe C, Trudeau LE. The role of neurotensin in central nervous system pathophysiology: what is the evidence?. J. Psychiat. Neurosci. 2006;31:229–245
  74. Szigethy E, Leonard K, Beaudet A. Ultrastructural localization of [125I]neurotensin binding sites to cholinergic neurons of the rat nucleus basalis magnocellularis. Neuroscience. 1990;36:377–391
  75. Tyler-McMahon BM, Boules M, Richelson E. Neurotensin: peptide for the next millennium. Regul. Pept. 2000;93:125–136
  76. Uhl GR, Snyder SH. Regional and subcellular distributions of brain neurotensin. Life Sci. 1976;19:1827–1832
  77. van der Beek EM, Wiegant VM, van der Donk HA, van den Hurk R, Buijs RM. Lesions of the suprachiasmatic nucleus indicate the presence of a direct vasoactive intestinal polypeptide-containing projection to gonadotrophin-releasing hormone neurons in the female rat. J. Neuroendocrinol. 1993;5:137–144
  78. Vijayan E, Carraway R, Leeman SE, McCann SM. Physiological significance of neurotensin in pituitary glycoprotein hormone release as revealed by in vivo and in vitro studies with neurotensin antiserum. Neuroendocrinology. 1994;60:157–164
  79. Villeneuve P, Feliciangeli S, Croissandeau G, Seidah NG, Mbikay M, Kitabgi P, et al. Altered processing of the neurotensin/neuromedin N precursor in PC2 knock down mice. a biochemical and immunohistochemical study. J. Neurochem. 2002;82:783–793
  80. Vincent B, Vincent JP, Checler F. Neurotensin and neuromedin N undergo distinct catabolic processes in murine astrocytes and primary cultured neurons. Eur. J. Biochem. 1994;221:297–306
  81. Vincent JP, Mazella J, Kitabgi P. Neurotensin and neurotensin receptors. Trends Pharmacol. Sci. 1999;20:302–309
  82. Vita N, Laurent P, Lefort S, Chalon P, Dumont X, Kaghad M, et al. Cloning and expression of a complementary DNA encoding a high affinity human neurotensin receptor. FEBS Lett. 1993;317:139–142
  83. von Euler G, Meister B, Hökfelt T, Eneroth P, Fuxe K. Intraventricular injection of neurotensin reduces dopamine D2 agonist binding in rat forebrain and intermediate lobe of the pituitary gland. Relationship to serum hormone levels and nerve terminal coexistence. Brain Res. 1990;531:253–262
  84. Walker N, Lepee-Lorgeoux I, Fournier J, Betancur C, Rostene W, Ferrara P, et al. Tissue distribution and cellular localization of the levocabastine-sensitive neurotensin receptor mRNA in adult rat brain. Brain Res. Mol. Brain Res. 1998;57:193–200
  85. Watanobe H, Takebe K. In vivo release of neurotensin from the median eminence of ovariectomized estrogen-primed rats as estimated by push–pull perfusion: correlation with luteinizing hormone and prolactin surges. Neuroendocrinology. 1993;57:760–764
  86. Watts AG, Sanchez-Watts G. Region-specific regulation of neuropeptide mRNAs in rat limbic forebrain neurones by aldosterone and corticosterone. J. Physiol. 1995;484:721–736
  87. Wilding JP, Gilbey SG, Bailey CJ, Batt RA, Williams G, Ghatei MA, et al. Increased neuropeptide-Y messenger ribonucleic acid (mRNA) and decreased neurotensin mRNA in the hypothalamus of the obese (ob/ob) mouse. Endocrinology. 1993;132:1939–1944
  88. Yamada M, Yamada M, Lombet A, Forgez P, Rostène W. Distinct functional characteristics of levocabastine sensitive rat neurotensin NT2 receptor expressed in Chinese hamster ovary cells. Life Sci. 1998;62:375–380
  89. Yamada M, Yamada M, Watson MA, Richelson E. Deletion mutation in the putative third intracellular loop of the rat neurotensin receptor abolishes polyphosphoinositide hydrolysis but not cyclic AMP formation in CHO-K1 cells. Mol. Pharmacol. 1994;46:470–476
  90. Zahm DS, Grosu S, Williams EA, Qin S, Bérod A. Neurons of origin of the neurotensinergic plexus enmeshing the ventral tegmental area in rat: retrograde labeling and in situ hybridization combined. Neuroscience. 2001;104:841–851

PII: S0143-4179(09)00109-7

doi: 10.1016/j.npep.2009.09.005

Neuropeptides
Volume 44, Issue 1 , Pages 1-7 , February 2010