Neuropeptides
Volume 43, Issue 5 , Pages 355-362 , October 2009

Endogenous peptide: Met-enkephalin-Arg-Phe, differently regulate expression of opioid receptors on chronic treatment

  • Ishwar Dutt Vats

      Affiliations

    • Peptide Synthesis Laboratory, Institute of Genomics and Integrative Biology, Delhi, India
    • Department of Chemistry, University of Delhi, Delhi, India
    • ,
  • Snehlata Chaudhary

      Affiliations

    • Peptide Synthesis Laboratory, Institute of Genomics and Integrative Biology, Delhi, India
    • ,
  • Jayashree Karar

      Affiliations

    • Functional Genomics Unit, Institute of Genomics and Integrative Biology, Delhi, India
    • ,
  • Mahendra Nath

      Affiliations

    • Department of Chemistry, University of Delhi, Delhi, India
    • ,
  • Qadar Pasha

      Affiliations

    • Functional Genomics Unit, Institute of Genomics and Integrative Biology, Delhi, India
    • ,
  • Santosh Pasha

      Affiliations

    • Peptide Synthesis Laboratory, Institute of Genomics and Integrative Biology, Delhi, India
    • Corresponding Author InformationCorresponding author. Address: Peptide Synthesis Laboratory, Institute of Genomics and Integrative Biology, Mall Road, Delhi 110 007, India. Tel.: +91 011 27666156; fax: +91 011 27667471.

Received 13 March 2009 ,Accepted 26 July 2009.

Reference 

  1. Akahori K, Kosaka K, Jin XL, Arai Y, Yoshikawa M, Kobayashi H, et al. Great increase in antinociceptive potency of [Leu5]enkephalin after peptidase inhibition. J. Pharmacol. Sci. 2008;106:295–300
  2. Attali B, Gouarderes C, Mazarguil H, Audigier Y, Cros J. Differential interaction of opiates to multiple “kappa” binding sites in the guinea-pig lumbo-sacral spinal cord. Life Sci. 1982;31:1371–1375
  3. Attali B, Gouarderes C, Mazarguil H, Audigier Y, Cros J. Evidence for multiple “Kappa” binding sites by use of opioid peptides in the guinea-pig lumbo-sacral spinal cord. Neuropeptides. 1982;3:53–64
  4. Benyhe S, Simon J, Borsodi A, Wollemann M, Barnard EA. [3H]Dynorphin1–8 binding sites in frog (Rana esculenta) brain membranes. Neuropeptides. 1994;26(5):359–364
  5. Benyhe S, Farkas J, Toth G, Wollemann M. Met5-enkephalin-Arg6–Phe7, an endogenous neuropeptide, binds to multiple opioid and nonopioid sites in rat brain. J. Neurosci. Res. 1997;48:249–258
  6. Benyhe S, Farkas J, Toth G, Wollemann M. Characterization of [3H]Met-enkephalin-Arg6–Phe7 binding to multiple sites in rat and guinea pig cerebellum. Life Sci. 1999;64:1189–1196
  7. Bhargava HN, Matwyshyn GA, Reddy PL, Veeranna . Effects of naltrexone on the binding of [3H]D-Ala2, MePhe4, Gly-ol5-enkephalin to brain regions and spinal cord and pharmacological responses to morphine in the rat. General Pharmacology. 1993;24:1351–1357
  8. Bhargava HN, Cao YJ, Zhao GM. Effect of 7-nitroindazole on tolerance to morphine, U-50, 488H and [D-Pen2, D-Pen5] enkephalin in mice. Peptides. 1997;18:797–800
  9. Burford NT, Tolbert LM, Sadee W. Specific G protein activation and μ-opioid receptor internalization caused by morphine, DAMGO and endomorphin I. Eur. J. Pharmacol. 1998;342:123–126
  10. Buzas B, Cox BM. Quantitative analysis of μ and δ opioid receptor gene expression in rat brain and peripheral ganglia using competitive polymerase chain reaction. Neuroscience. 1997;76:479–489
  11. Clarke S, Zimmer A, Zimmer AM, Hill RG, Kitchen I. Region selective up-regulation of micro-, delta- and kappa-opioid receptors but not opioid receptor-like 1 receptors in the brains of enkephalin and dynorphin knockout mice. Neuroscience. 2003;122:479–489
  12. Galina ZH, Kastin AJ. Existence of antiopiate systems as illustrated by MIF-1/Tyr-MIF-1. Life Sci. 1986;39:2153–2159
  13. Gayton RJ. Mammalian neuronal actions of FMRFamide and the structurally related opioid Met-enkephalin-Arg6–Phe7. Nature. 1982;298:275–276
  14. Giraud P, Castanas E, Patey G, Oliver C, Rossier J. Regional distribution of methionine-enkephalin-Arg6–Phe7 in the rat brain: comparative study with the distribution of other opioid peptides. J. Neurochem. 1983;41:154–160
  15. Goodman, C.B., Elmer, G.I., Yang, H.-Y.T., Lee, CH., Rothman, R.B., 1995. Modulation of opioid receptors by antiopioid peptides. In: Tseng, L.F. (Ed.), The Pharmacology of Opioid Peptides. Harwood Academic Publishers, Singapore, GMBH pp. 303–319.
  16. Gupta S, Pasha S, Gupta YK, Bhardwaj DK. Chimeric peptide of Met-enkephalin and FMRFa induces antinociception and attenuates development of tolerance to morphine antinociception. Peptides. 1999;20:471–478
  17. Horner KA, Zadina JE. Internalization and down-regulation of mu opioid receptors by endomorphins and morphine in SH-SY5Y human neuroblastoma cells. Brain Res. 2004;1028:121–132
  18. Inturrisi CE, Umans JG, Wolff D, Stern AS, Lewis RV, Stein S, et al. Analgesic activity of the naturally occurring heptapeptide [Met]enkephalin-Arg6–Phe7. Proc. Natl. Acad. Sci. 1980;77:5512–5514
  19. Kamei J, Iwamoto Y, Misawa M, Nagase H, Kasuya Y. Antitussive effect of [Met5]enkephalin-Arg6–Phe7 in mice. Eur. J. Pharmacol. 1994;253:293–296
  20. Kilpatrick DL, Howells RD, Lahm HW, Udenfriend S. Evidence for a proenkephalin-like precursor in amphibian brain. Proc. Natl. Acad. Sci. USA. 1983;80:5772–5775
  21. Kim KW, Woo RS, Kim CJ, Cheong YP, Kim JK, Kwun J, et al. Receptor selectivity of Met-enkephalin-Arg6–Phe7, an endogenous opioid peptide, in cerebral cortex of human and rat. Life Sci. 2000;67:61–71
  22. Law PY, Louie AK, Loh HH. Effect of pertussis toxin treatment on the down-regulation of opiate receptors in neuroblastoma×glioma NG108-15 hybrid cells. J. Biol. Chem. 1985;260:14818–14823
  23. Lee SC, Yoburn BC. The effect of nimodipine on opioid antagonist-induced upregulation and supersensitivity. Pharmacol. Biochem. Behav. 2000;66:347–351
  24. Majane EA, Iadarola MJ, Yang HY. Distribution of Met5-enkephalin-Arg6, Phe7 in rat spinal cord. Brain Res. 1983;264:336–339
  25. Mathis JP, Ryan-moro J, Chang A, Hom JS, Scheinberg DA, Pasternak GW. Biochemical evidence for orphanin FQ/nociceptin receptor heterogeneity in mouse brain. Biochem. Biophys. Res. Commun. 1997;230:462–465
  26. Mcconalogue K, Grady EF, Minnis J, Balestra B, Tonini M, Brecha NC, et al. Activation and internalization of the mu-opioid receptor by the newly discovered endogenous agonists, endomorphin-1 and endomorphin-2. Neuroscience. 1999;90:1051–1059
  27. Paterson SJ, Corbett AD, Gillan MG, Kosterlitz HW, Mcknight AT, Robson LE. Radioligands for probing opioid receptors. J. Recept. Res. 1984;4:143–154
  28. Payza K, Akar CA, Yang HY. Neuropeptide FF receptors: structure-activity relationship and effect of morphine. J. Pharmacol. Exp. Ther. 1993;267:88–94
  29. Raffa RB. The action of FMRFamide (Phe-Met-Arg-Phe-NH2) and related peptides on mammals. Peptides. 1988;9:915–922
  30. Raffa RB, Baldy WJ, Shank RP, Mathiasen JR, Vaught JL. [3H][D-Ala2, NMePhe4, Gly-ol5]-enkephalin (mu-opioid) binding in beige-J mice. Peptides. 1988;9:637–642
  31. Rossier J, Audigier Y, Ling N, Cros J, Udenfriend S. Met-enkephalin-Arg6–Phe7, present in high amounts in brain of rat, cattle and man, is an opioid agonist. Nature. 1980;288:88–90
  32. Rothman RB. A review of the role of anti-opioid peptides in morphine tolerance and dependence. Synapse. 1992;12:129–138
  33. Stern AS, Lewis RV, Kimura S, Rossier J, Gerber LD, Brink L, et al. Isolation of the opioid heptapeptide Met-enkephalin [Arg6, Phe7] from bovine adrenal medullary granules and striatum. Proc. Natl. Acad. Sci. USA. 1979;76:6680–6683
  34. Takahashi S, Jin XL, Kosaka K, Yoshikawa M, Kobayashi H, Oka T. The enhancing effects of peptidase inhibitors on the antinociceptive action of [Met5]enkephalin-arg6–phe7 in rats. J. Pharmacol. Sci. 2007;105:117–121
  35. Tang J, Yang HY, Costa E. Distribution of met-enkephalin-Arg6–Phe7 in various tissues of rats and guinea pigs. Neuropharmacology. 1982;21:595–600
  36. Trafton, J.A., Basbaum, A.I., 2004. [d-Ala2,N-MePhe4,Gly-ol5]enkephalin-induced internalization of the micro opioid receptor in the spinal cord of morphine tolerant rats. Neuroscience 125, 541-543.
  37. Vats ID, Dolt KS, Kumar K, Karar J, Nath M, Mohan A, et al. YFa, a chimeric opioid peptide, induces kappa-specific antinociception with no tolerance development during 6 days of chronic treatment. J. Neurosci. Res. 2008;86:1599–1607
  38. Yang HY, Panula P, Tang J, Costa E. Characterization and location of Met5-enkephalin-arg6–phe7 stored in various rat brain regions. J. Neurochem. 1983;40:969–976
  39. Yang H-YT, Fratta W, Majane EA, Costa E. Isolation, sequencing, synthesis and pharmacological characterization of two brain neuropeptides that modulate the action of morphine. Proc. Natl. Acad. Sci. USA. 1985;82:7757–7761

PII: S0143-4179(09)00083-3

doi: 10.1016/j.npep.2009.07.003

Neuropeptides
Volume 43, Issue 5 , Pages 355-362 , October 2009

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