Neuropeptides
Volume 43, Issue 1 , Pages 21-29, February 2009

Possible role of the histaminergic system in autonomic and cardiovascular responses to neuropeptide Y

  • Mamoru Tanida

      Affiliations

    • Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan
    • ANBAS Corporation, Kita-ku, Osaka 531-0072, Japan
    • Institute for Protein Research, Osaka University, Suita, Osaka 565-0871, Japan
    • Corresponding Author InformationCorresponding author. Address: Department of Biomedical Sciences, College of Life Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan. Tel.: +81 77 561 3378; fax: +81 77 561 6569.
    • ,
  • Jiao Shen

      Affiliations

    • ANBAS Corporation, Kita-ku, Osaka 531-0072, Japan
    • Institute for Protein Research, Osaka University, Suita, Osaka 565-0871, Japan
    • ,
  • Katsuya Nagai

      Affiliations

    • ANBAS Corporation, Kita-ku, Osaka 531-0072, Japan
    • Institute for Protein Research, Osaka University, Suita, Osaka 565-0871, Japan

Received 20 May 2008; accepted 30 September 2008. published online 10 November 2008.

Abstract 

Previous studies have demonstrated that neuropeptide Y (NPY) affects blood pressure (BP) in anesthetized rats. Here, we examined the effects of the third cerebral ventricular (3CV) injection of various doses of NPY on renal sympathetic nerve activity (RSNA) and BP in anesthetized rats. 3CV injection of NPY suppressed RSNA and BP in a dose-dependent manner.

Moreover, suppressing effects of NPY on RSNA and BP were eliminated by lateral cerebral ventricular (LCV) preinjection of thioperamide, an antagonist of histaminergic H3-receptor, not diphenhydramine, an antagonist of histaminergic H1-receptor. In addition, 3CV injection of NPY accelerated gastric vagal nerve activity (GVNA) and inhibited brown adipose tissue sympathetic nerve activity (BAT-SNA) of anesthetized rats, and lowered brown adipose tissue temperature (BAT-T) of conscious rats. Thus, these evidences suggest that central NPY affects autonomic nerves containing RSNA, GVNA or BAT-SNA, and BP by mediating central histaminergic H3-receptors.

Keywords: NPY, Histamine-H1-receptor, Renal sympathetic nerve, Stomach, Brown adipose tissue, Blood pressure

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PII: S0143-4179(08)00111-X

doi:10.1016/j.npep.2008.09.007

Neuropeptides
Volume 43, Issue 1 , Pages 21-29, February 2009

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