Neuropeptides
Volume 41, Issue 1 , Pages 33-38 , February 2007

S-(+)-fenfluramine-induced nociceptive behavior in mice: Involvement of interactions between spinal serotonin and substance P systems

  • Koichi Tan-No

      Affiliations

    • Department of Pharmacology, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 22 727 0123; fax: +81 22 275 2013.
  • ,
  • Katsuaki Takahashi

      Affiliations

    • Department of Pharmacology, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan
  • ,
  • Masakazu Shimoda

      Affiliations

    • Department of Pharmacology, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan
  • ,
  • Mai Sugawara

      Affiliations

    • Department of Pharmacology, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan
  • ,
  • Osamu Nakagawasai

      Affiliations

    • Department of Pharmacology, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan
  • ,
  • Fukie Niijima

      Affiliations

    • Department of Pharmacology, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan
  • ,
  • Takumi Sato

      Affiliations

    • Department of Pharmacology and Pharmacotherapy, Nihon Pharmaceutical University, Kitaadachi-gun, Saitama 362-0806, Japan
  • ,
  • Susumu Satoh

      Affiliations

    • Department of Pharmacology and Pharmacotherapy, Nihon Pharmaceutical University, Kitaadachi-gun, Saitama 362-0806, Japan
  • ,
  • Takeshi Tadano

      Affiliations

    • Department of Pharmacology, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan

Received 12 August 2006 ,Accepted 11 October 2006.

References 

  1. Araneda R, Andrade R. 5-Hydroxytryptamine2 and 5-hydroxytryptamine1A receptors mediated opposing responses on membrane excitability in rat association cortex. Neuroscience. 1991;40:399–412
  2. Barnes NM, Sharp T. A review of central 5-HT receptors and their function. Neuropharmacology. 1999;38:1083–1152
  3. Bertelsen AK, Afrah AW, Gustafsson H, Tjølsen A, Hole K, Stiller C-O. Stimulation of spinal 5-HT2A/2C receptors potentiates the capsaicin-induced in vivo release of substance P-like immunoreactivity in the rat dorsal horn. Brain Research. 2003;987:10–16
  4. Brandao ML, Lopez-Garcia JA, Graeff FG, Roberts MHT. Electrophysiological evidence for excitatory 5-HT2 and depressant 5-HT1A receptors on neurons of the rat midbrain tectum. Brain Research. 1991;556:259–266
  5. De Vivo M, Maayani S. Characterization of the 5-hydroxytryptamine1A receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in guinea pig and rat hippocampal membranes. Journal of Pharmacology and Experimental Therapeutics. 1986;238:248–253
  6. Eide PK, Hole K. Interactions between serotonin and substance P in the spinal regulation of nociception. Brain Research. 1991;550:225–230
  7. Eide PK, Hole K. Different role of 5-HT1A and 5-HT2 receptors in spinal cord in the control of nociceptive responsiveness. Neuropharmacology. 1991;30:727–731
  8. Eide PK, Hole K. The role of 5-hydroxytryptamine (5-HT) receptor subtypes and plasticity in the 5-HT systems in the regulation of nociceptive sensitivity. Cephalalgia. 1993;13:75–85
  9. El-Yassir N, Fleetwood-Walker SM, Mitchell R. Heterogeneous effects of serotonin in the dorsal horn of rat: the involvement of 5-HT1 receptor subtypes. Brain Research. 1988;456:147–158
  10. Fields HL, Heinricher MM, Mason P. Neurotransmitters in nociceptive modulatory circuits. Annual Review of Neuroscience. 1991;14:219–245
  11. Fozard JR. 5-HT: the enigma variations. Trends in Pharmacological Sciences. 1987;8:501–506
  12. Furst S. Transmitters involved in antinociception in the spinal cord. Brain Research Bulletin. 1999;48:129–141
  13. Hoyer D, Clarke DE, Fozard JR, Harting PR, Martin GR, Mylecharane EJ, et al. International union of pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). Pharmacological Review. 1994;46:157–203
  14. Hylden JLK, Wilcox GL. Intrathecal morphine in mice, a new technique. European Journal Pharmacology. 1980;67:313–316
  15. Johansson O, Hökfelt T, Pernow B, Jeffcoate SL, White N, Steinbusch HWM, et al. Immunohistochemical support for three putative transmitters in one neuron: coexistence of 5-hydroxytryptamine, substance P- and thyrotropin releasing hormone-like immunoreactivity in medullary neurons projecting to the spinal cord. Neuroscience. 1981;6:1857–1881
  16. Mjellem N, Lund A, Hole K. Different functions of spinal 5-HT1A and 5-HT2 receptor subtypes in modulating behaviour induced by excitatory amino acid receptor agonists in mice. Brain Research. 1993;626:78–82
  17. Sakurada T, Yamada T, Tan-No K, Manome Y, Sakurada S, Kisara K, et al. Differential effects of substance P analogs on neurokinin 1 receptor agonists in the mouse spinal cord. Journal of Pharmacology and Experimental Therapeutics. 1991;259:205–210
  18. Sakurada T, Manome Y, Tan-No K, Matsunaga Y, Sakurada S, Kisara K. Possible involvement of the spinal substance P system in pilocarpine-induced scratching in mice. Pharmacology Biochemistry and Behavior. 1993;44:439–445
  19. Sakurada T, Wako K, Sakurada C, Manome Y, Tan-No K, Sakurada S, et al. Spinally-mediated behavioural responses evoked by intrathecal high-dose morphine: possible involvement of substance P in the mouse spinal cord. Brain Research. 1996;724:213–221
  20. Sakurada T, Sakurada C, Tan-No K, Kisara K. Neurokinin receptor antagonists. Therapeutic potential in the treatment of pain syndromes. CNS Drugs. 1997;8:436–447
  21. Sakurada T, Katsuyama S, Sakurada S, Inoue M, Tan-No K, Kisara K, et al. Nociceptin-induced scratching, biting and licking in mice: involvement of spinal NK1 receptors. British Journal of Pharmacology. 1999;127:1712–1718
  22. Takahashi K, Sakurada T, Sakurada S, Kuwahara H, Yonezawa A, Ando R, et al. Behavioural characterization of substance P-induced nociceptive response in mice. Neuropharmacology. 1987;26:1289–1293
  23. Tan-No K, Taira A, Sakurada T, Inoue M, Sakurada S, Tadano T, et al. Inhibition of dynorphin-converting enzymes prolongs the antinociceptive effect of intrathecally administered dynorphin in the mouse formalin test. European Journal of Pharmacology. 1996;314:61–67
  24. Tan-No K, Taira A, Wako K, Niijima F, Nakagawasai O, Tadano T, et al. Intrathecally administered spermine produces the scratching, biting and licking behavior in mice. Pain. 2000;86:55–61
  25. Tan-No K, Esashi A, Nakagawasai O, Niijima F, Tadano T, Sakurada C, et al. Intrathecally administered big dynorphin, a prodynorphin-derived peptide, produces nociceptive behavior through an N-methyl-d-aspartate receptor mechanism. Brain Research. 2002;952:7–14
  26. Tan-No K, Esashi A, Taira A, Nakagawasai O, Niijima F, Sakurada C, et al. Intrathecal spermine and spermidine at high-doses induce antinociceptive effects in the mouse capsaicin test. Biogenic Amines. 2003;17:313–320
  27. Tan-No K, Takahashi H, Nakagawasai O, Niijima F, Sato T, Satoh S, et al. Pronociceptive role of dynorphins in uninjured animals: N-ethylmaleimide-induced nociceptive behavior mediated through inhibition of dynorphin degradation. Pain. 2005;113:301–309
  28. Tan-No K, Taira A, Nakagawasai O, Niijima F, Demuth H-U, Silberring J, et al. Differential effects of N-peptidyl-O-acyl hydroxylamines on dynorphin-induced antinociception in the mouse capsaicin test. Neuropeptides. 2005;39:569–573

PII: S0143-4179(06)00143-0

doi: 10.1016/j.npep.2006.10.003

Neuropeptides
Volume 41, Issue 1 , Pages 33-38 , February 2007