Neuropeptides
Volume 41, Issue 1 , Pages 45-49 , February 2007

d-Lys-GHRP-6 does not modify the endocrine response to acylated ghrelin or hexarelin in humans

  • A. Benso

      Affiliations

    • Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Turin, Italy
    • First co-authorship.
  • ,
  • F. Prodam

      Affiliations

    • Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Turin, Italy
    • First co-authorship.
  • ,
  • B. Lucatello

      Affiliations

    • Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Turin, Italy
  • ,
  • E. Gramaglia

      Affiliations

    • Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Turin, Italy
  • ,
  • F. Riganti

      Affiliations

    • Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Turin, Italy
  • ,
  • H. Schneider

      Affiliations

    • Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Turin, Italy
  • ,
  • A.J. van der Lely

      Affiliations

    • Division of Endocrinology, Department of Internal Medicine, Erasmus University Rotterdam, Rotterdam, The Netherlands
  • ,
  • G. Muccioli

      Affiliations

    • Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, Turin, Italy
  • ,
  • E. Ghigo

      Affiliations

    • Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Turin, Italy
  • ,
  • F. Broglio

      Affiliations

    • Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Turin, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39 0116334317; fax: +39 011 6647421.

Received 17 August 2006 ,Accepted 3 October 2006.

References 

  1. Beck B, Richy S, Stricker-Krongrad A. Feeding response to ghrelin agonist and antagonist in lean and obese Zucker rats. Life Sci. 2004;76:473–478
  2. Broglio F, Prodam F, Riganti F, Muccioli G, Ghigo E. Ghrelin: from somatotrope secretion to new perspectives in the regulation of peripheral metabolic functions. Front Horm. Res. 2006;35:102–114
  3. Chen X, Ge YL, Jiang ZY, Liu CQ, Depoortere I, Peeters TL. Effects of ghrelin on hypothalamic glucose responding neurons in rats. Brain Res. 2005;1055:131–136
  4. Cheng K, Chan WW, Barreto A, Convey EM, Smith RG. The synergistic effects of His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 on growth hormone (GH)-releasing factor-stimulated GH release and intracellular adenosine 3′,5′-monophosphate accumulation in rat primary pituitary cell culture. Endocrinology. 1989;124:2791–2798
  5. Cheng K, Wei L, Chaung LY, Chan WW, Butler B, Smith RG. Inhibition of L-692,429-stimulated rat growth hormone release by a weak substance P antagonist: L-756,867. J. Endocrinol. 1997;152:155–158
  6. Conconi MT, Nico B, Guidolin D, Baiguera S, Spinazzi R, Rebuffat P, et al. Ghrelin inhibits FGF-2-mediated angiogenesis in vitro and in vivo. Peptides. 2004;25:2179–2185
  7. Dong J, Peeters TL, De SB, Moechars D, Delporte C, Vanden BP, et al. Role of endogenous ghrelin in the hyperphagia of mice with streptozotocin-induced diabetes. Endocrinology. 2006;147:2634–2642
  8. Duxbury MS, Waseem T, Ito H, Robinson MK, Zinner MJ, Ashley SW, et al. Ghrelin promotes pancreatic adenocarcinoma cellular proliferation and invasiveness. Biochem. Biophys. Res. Commun. 2003;309:464–468
  9. Fukushima N, Hanada R, Teranishi H, Fukue Y, Tachibana T, Ishikawa H, et al. Ghrelin directly regulates bone formation. J. Bone Miner. Res. 2005;20:790–798
  10. Glavaski-Joksimovic A, Jeftinija K, Scanes CG, Anderson LL, Jeftinija S. Stimulatory effect of ghrelin on isolated porcine somatotropes. Neuroendocrinology. 2003;77:367–379
  11. Halem HA, Taylor JE, Dong JZ, Shen Y, Datta R, Abizaid A, et al. Novel analogs of ghrelin: physiological and clinical implications. Eur. J. Endocrinol. 2004;151(Suppl. 1):S71–S75
  12. Halem HA, Taylor JE, Dong JZ, Shen Y, Datta R, Abizaid A, et al. A novel growth hormone secretagogue-1a receptor antagonist that blocks ghrelin-induced growth hormone secretion but induces increased body weight gain. Neuroendocrinology. 2005;81:339–349
  13. Horvath TL, Castaneda T, Tang-Christensen M, Pagotto U, Tschop MH. Ghrelin as a potential anti-obesity target. Curr. Pharm. Des. 2003;9:1383–1395
  14. Kim SW, Her SJ, Park SJ, Kim D, Park KS, Lee HK, et al. Ghrelin stimulates proliferation and differentiation and inhibits apoptosis in osteoblastic MC3T3-E1 cells. Bone. 2005;37:359–369
  15. Kitazawa T, De SB, Verbeke K, Depoortere I, Peeters TL. Gastric motor effects of peptide and non-peptide ghrelin agonists in mice in vivo and in vitro. Gut. 2005;54:1078–1084
  16. Kojima M, Kangawa K. Ghrelin: structure and function. Physiol Rev. 2005;85:495–522
  17. Korbonits M, Goldstone AP, Gueorguiev M, Grossman AB. Ghrelin – a hormone with multiple functions. Front Neuroendocrinol. 2004;25:27–68
  18. Ohinata K, Kobayashi K, Yoshikawa M. [Trp3, Arg5]-ghrelin(1-5) stimulates growth hormone secretion and food intake via growth hormone secretagogue (GHS) receptor. Peptides. 2006;27:1632–1637
  19. Okimura Y, Ukai K, Hosoda H, Murata M, Iguchi G, Iida K, et al. The role of circulating ghrelin in growth hormone (GH) secretion in freely moving male rats. Life Sci. 2003;72:2517–2524
  20. Pierno S, De LA, Desaphy JF, Fraysse B, Liantonio A, Didonna MP, et al. Growth hormone secretagogues modulate the electrical and contractile properties of rat skeletal muscle through a ghrelin-specific receptor. Br. J. Pharmacol. 2003;139:575–584
  21. Sibilia V, Muccioli G, Deghenghi R, Pagani F, De Luca V, Rapetti D, et al. Evidence for a role of the GHS-R1a receptors in ghrelin inhibition of gastric acid secretion in the rat. J. Neuroendocrinol. 2006;18:122–128
  22. Smith RG. Development of growth hormone secretagogues. Endocr. Rev. 2005;26:346–360
  23. Soares JB, Rocha-Sousa A, Castro-Chaves P, Henriques-Coelho T, Leite-Moreira AF. Inotropic and lusitropic effects of ghrelin and their modulation by the endocardial endothelium, NO, prostaglandins, GHS-R1a and KCa channels. Peptides. 2006;27:1616–1623
  24. Traebert M, Riediger T, Whitebread S, Scharrer E, Schmid HA. Ghrelin acts on leptin-responsive neurones in the rat arcuate nucleus. J. Neuroendocrinol. 2002;14:580–586
  25. Unniappan S, Peter RE. In vitro and in vivo effects of ghrelin on luteinizing hormone and growth hormone release in goldfish. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2004;286:R1093–R1101
  26. van der Lely AJ, Tschop M, Heiman ML, Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr. Rev. 2004;25:426–457
  27. Zizzari P, Halem H, Taylor J, Dong JZ, Datta R, Culler MD, et al. Endogenous ghrelin regulates episodic growth hormone (GH) secretion by amplifying GH Pulse amplitude: evidence from antagonism of the GH secretagogue-R1a receptor. Endocrinology. 2005;146:3836–3842

PII: S0143-4179(06)00116-8

doi: 10.1016/j.npep.2006.10.001

Neuropeptides
Volume 41, Issue 1 , Pages 45-49 , February 2007